Biodistribution and toxicology evaluation of a recombinant measles Schwarz‐based Lassa vaccine in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4421
Abstract: MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three… read more here.
Keywords: toxicology; measles schwarz; schwarz based; pathology ... See more keywords
Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2019 at "Abdominal Radiology"
DOI: 10.1007/s00261-019-01908-5
Abstract: PurposeThe aim of this study was to investigate the effectiveness of contrast-enhanced ultrasound (CEUS) in predicting early nephropathy in cynomolgus macaques with spontaneous type 2 diabetes mellitus (T2DM).MethodsSix cynomolgus macaques with spontaneous T2DM and six… read more here.
Keywords: cynomolgus macaques; group; value; enhanced ultrasound ... See more keywords
Body Weight and Anxiety in Cynomolgus Macaques (Macaca fascicularis) Males
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-021-05159-7
Abstract: We studied the relationship between body weight and behavioral characteristics (anxiety, social status, aggressive and exploratory behavior, and sociability) of socially housed adult male cynomolgus macaques. Of the studied parameters, only anxiety showed pronounced relationship… read more here.
Keywords: anxiety; cynomolgus macaques; relationship body; body weight ... See more keywords
Functional and molecular characterization of UDP‐glucuronosyltransferase 2 family in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.03.002
Abstract: Graphical abstract Figure. No caption available. &NA; UDP‐glucuronosyltransferases (UGTs) are essential enzymes metabolizing endogenous and exogenous chemicals. However, characteristics of UGTs have not been fully investigated in molecular levels of cynomolgus macaques, one of non‐human… read more here.
Keywords: molecular characterization; functional molecular; udp glucuronosyltransferase; cynomolgus macaques ... See more keywords
Section 4: Immunopharmacology
Sign Up to like & getrecommendations! Published in 2017 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.67
Abstract: Doi: 10.1038/aps.2017.67 S4.1 Naturally existing oncolytic virus M1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections Hai-peng ZHANG, Yuan LIN, Kai LI, Jian-kai LIANG, Xiao XIAO, Guang-mei YAN, Yuan LIN… read more here.
Keywords: administration; oncolytic virus; cynomolgus macaques; section immunopharmacology ... See more keywords
An optimized purified inactivated Zika vaccine provides sustained immunogenicity and protection in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-0167-8
Abstract: The recent spread of Zika virus (ZIKV) through the Americas and Caribbean and its devastating consequences for pregnant women and their babies have driven the search for a safe and efficacious ZIKV vaccine. Among the… read more here.
Keywords: protection; zpiv; cynomolgus macaques; zikv ... See more keywords
Phenotypic and Kinetic Changes of Myeloid Lineage Cells in Innate Response to Chikungunya Infection in Cynomolgus Macaques.
Sign Up to like & getrecommendations! Published in 2022 at "Viral immunology"
DOI: 10.1089/vim.2021.0171
Abstract: Chikungunya (CHIKV) is an emerging worldwide viral threat. The immune response to infection can lead to protection and convalescence or result in long-term sequelae such as arthritis. Early innate immune events during acute infection have… read more here.
Keywords: myeloid lineage; infection; changes myeloid; cynomolgus macaques ... See more keywords
Gene flow from rhesus (Macaca mulatta) to cynomolgus macaques (M. fascicularis) and effects of introgressive hybridization on reproduction in two biomedically relevant non‐human primate species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12570
Abstract: We compared the reproductive patterns of wild Indochinese and Sundaic cynomolgus macaques (Mf) exhibiting different levels of genetic admixture with rhesus macaques (Mm). read more here.
Keywords: gene flow; cynomolgus; rhesus macaca; flow rhesus ... See more keywords
Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00728-22
Abstract: The world remains at risk of an influenza pandemic, and the development of new therapeutic and preventative modalities is critically important for minimizing human death and suffering during the next influenza pandemic. Animal models are… read more here.
Keywords: 1918 influenza; rhesus; influenza; influenza pandemic ... See more keywords
Abstract 1815: Rapid serial killing of target cells by Vγ9Vδ2 T Cells in cynomolgus macaques and humanized mice treated with a CD20-directed heterodimeric butyrophilin 2A1/3A1 fusion protein
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1815
Abstract: CD3-directed T cell engagers provide clinical benefit in a variety of hematologic cancers, but it remains unclear whether γδ T cells (GDT) are present at sufficient numbers to be similarly harnessed because they represent only… read more here.
Keywords: cell; cd20; 2a1 3a1; depletion ... See more keywords
Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques
Sign Up to like & getrecommendations! Published in 2022 at "Toxicologic Pathology"
DOI: 10.1177/01926233221084634
Abstract: Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to… read more here.
Keywords: cynomolgus macaques; rhesus cynomolgus; gastrointestinal tract;