A cynomolgus monkey model of temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.11.001
Abstract: Temporal lobe epilepsy (TLE) with hippocampal sclerosis is the most common type of drug-resistant epilepsy. Non-human primates are attractive models for studying the pathogenic mechanisms of TLE, with the goal of developing new drugs and… read more here.
Keywords: epilepsy; model; cynomolgus monkey; temporal lobe ... See more keywords
Comparison of the inducibility of CYP mRNA exposed to typical inducers in fresh and cryopreserved cynomolgus monkey hepatocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.03.001
Abstract: Herein, we evaluated CYPs and their nuclear receptor mRNA induction by exposure to typical inducers, omeprazole, rifampicin, and phenobarbital in cynomolgus monkey hepatocytes. Six freshly-isolated hepatocytes and 6 cryopreserved hepatocytes from cynomolgus monkey liver were… read more here.
Keywords: cyp mrna; cynomolgus monkey; culture; typical inducers ... See more keywords
Minimal physiologically‐based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti‐VEGF humanized IgG1 antibody in cynomolgus monkey
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.09.015
Abstract: &NA; In this study, we developed a first minimal physiologically‐based pharmacokinetic (mPBPK) model to investigate the complex interaction effects of endocytosis rate/FcRn binding affinity at both acidic/physiological pH on the pharmacokinetics (PK) of the anti‐VEGF… read more here.
Keywords: anti vegf; igg1; model; fcrn ... See more keywords
Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45285
Abstract: Experimental animal models have played an indispensable role in the development of human induced pluripotent stem cell (iPSC) research. The derivation of high-quality (so-called “true naïve state”) iPSCs of non-human primates enhances their application and… read more here.
Keywords: conversion; stem cell; pluripotent stem; cynomolgus monkey ... See more keywords
Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2018.1462429
Abstract: ABSTRACT The linear pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) can be considered a class property with values that are similar to endogenous IgG. Knowledge of these parameters across species could be used to avoid… read more here.
Keywords: poppk; monoclonal antibodies; human cynomolgus; cynomolgus monkey ... See more keywords
In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ophthalmology"
DOI: 10.1155/2020/1848540
Abstract: Purpose To seek for a small interfering RNA (siRNA) sequence targeting a cynomolgus monkey inhibitor of nuclear factor kappa B α (IκBα) that can specifically and effectively suppress IκBα gene expression of cynomolgus monkey ciliary… read more here.
Keywords: transfection concentration; cells cells; transfection; cynomolgus monkey ... See more keywords
Testicular microlithiasis in a clinically healthy cynomolgus monkey (Macaca fascicularis)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2017-0065
Abstract: The present article describes an occurrence of testicular microlithiasis in a cynomolgus monkey from a routine regulatory toxicology study. The monkey was from a negative control group. Microscopically, the lesion was characterized by multiple extracellular… read more here.
Keywords: toxicology; cynomolgus monkey; testicular microlithiasis;
Lipomatosis of axillary lymph nodes in a cynomolgus monkey (Macaca fascicularis)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2021-0054
Abstract: Lipomatosis of lymph nodes is defined as the replacement of the lymphatic parenchyma by adipose tissue which grows in the node from the hilus toward the cortical zone. In humans, it is considered as part… read more here.
Keywords: cynomolgus monkey; axillary lymph; lymph nodes; lymph ... See more keywords
The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.587149
Abstract: Purpose: Doxorubicin-related heart failure has been recognized as a serious complication of cancer chemotherapy. This paper describes a cardiovascular safety pharmacology study with chronic dosing of doxorubicin in a non-human primate model designed to characterize… read more here.
Keywords: repeat dose; study; cynomolgus monkey; doxorubicin ... See more keywords
Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1055031
Abstract: We studied time course of pathological remodeling occurring in the cynomolgus monkey hearts against persistent atrioventricular block condition (n = 10). The atrioventricular block induced the ventricular and atrial dilation followed by the ventricular hypertrophy.… read more here.
Keywords: cynomolgus monkey; pathological remodeling; chronic atrioventricular; atrioventricular block ... See more keywords
Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2023.1106016
Abstract: Introduction Polycystic kidney disease (PKD) is a common autosomal dominant or recessive genetic disease, often accompanied by polycystic liver disease (PLD). Many cases of PKD in animals have been reported. However, little is known about… read more here.
Keywords: cynomolgus monkey; disease; etiology; polycystic kidney ... See more keywords