Antidiabetic Effect of Abextide, a Long-Acting Exendin-4 Analogue in Cynomolgus Monkeys.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201800686
Abstract: Abextide, synthesized by conjugating an albumin-binding moiety-truncated Evans blue-to glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4, shows extended drug release and enhanced hypoglycemic effect in diabetic mice. The aim of this study is to evaluate… read more here.
Keywords: exendin; effect abextide; cynomolgus monkeys; group ... See more keywords
Engineered FcRn Binding Fusion Peptides Significantly Enhance the Half-Life of a Fab Domain in Cynomolgus Monkeys.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201800007
Abstract: There is a rapidly growing reinvigoration of the investigation of small proteins, cyclic peptides, and mAb derived domains as biotherapies. The drugability of these structures are challenged by fast peripheral clearance properties that can reduce… read more here.
Keywords: fcrn binding; cynomolgus monkeys; fab; fusion ... See more keywords
Pharmacokinetic profiles of a SARS‐COV‐2 neutralizing antibody BD‐604 in cynomolgus monkeys
Sign Up to like & getrecommendations! Published in 2021 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3122
Abstract: Abstract Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has spread worldwide as a severe pandemic and effective therapeutic medications are urgently needed. As reported previously, BD‐604 is a fully human monoclonal antibody with… read more here.
Keywords: 604 cynomolgus; cynomolgus monkeys; pharmacokinetic profiles; antibody ... See more keywords
Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.035
Abstract: Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental… read more here.
Keywords: talen edited; cynomolgus monkeys; rett syndrome; mutant cynomolgus ... See more keywords
Chronic sub-anesthetic ketamine induces permanent hypolocomotion and impairment of hippocampus in adolescent cynomolgus monkeys
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134702
Abstract: Ketamine has gained increasing popularity in adolescent drug abusers worldwide. However, relatively little is known about the long-term effects of recreational ketamine on adolescent hippocampus. The present study investigates the effects of different periods (1,… read more here.
Keywords: hippocampus adolescent; cynomolgus monkeys; ketamine; hippocampus ... See more keywords
Daily ascending dosing in cynomolgus monkeys to mitigate cytokine release syndrome induced by ERY22, surrogate for T-cell redirecting bispecific antibody ERY974 for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114657
Abstract: CD3 bispecific constructs show promising therapeutic potential as anti-tumor antibodies, but it has concurrently been difficult to manage cytokine release syndrome (CRS) in clinical use. Currently, the most effective measure for reducing CRS is considered… read more here.
Keywords: daily ascending; cynomolgus monkeys; release syndrome; cytokine release ... See more keywords
Simultaneous Subtotal Pancreatectomy and Streptozotocin Injection for Diabetes Modeling in Cynomolgus Monkeys.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2017.03.012
Abstract: BACKGROUND In an experimental animal model of islet transplantation, stable induction of insulin-dependent diabetes mellitus (IDDM) and islet isolation from donor pancreas are essential. Total pancreatectomy for IDDM induction and islet procurement in nonhuman primates… read more here.
Keywords: pancreatectomy; simultaneous subtotal; islet; subtotal pancreatectomy ... See more keywords
A safety and immunogenicity study of immunization with hVEGF26-104/RFASE in cynomolgus monkeys.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.02.066
Abstract: INTRODUCTION Vascular endothelial growth factor (VEGF) is pivotal in tumor angiogenesis and therapies targeting the VEGF axis are widely used in the clinic for the treatment of cancer. We have developed a therapeutic vaccine targeting… read more here.
Keywords: rfase; immunization; hvegf26 104; immunogenicity ... See more keywords
Impact of housing conditions on cardiovascular parameters in telemetry-implanted cynomolgus monkeys
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacological and Toxicological Methods"
DOI: 10.1016/j.vascn.2020.106812
Abstract: The European Directive dedicated to the protection of animals used for scientific purposes, 2010/63/EU clearly indicates that animals, except those which are naturally solitary, should be socially housed in stable groups of compatible individuals. It… read more here.
Keywords: group housing; implanted cynomolgus; cynomolgus monkeys; housing ... See more keywords
Quantitative Proteomic Analysis of Serum Reveals MST1 as a Potential Candidate Biomarker in Spontaneously Diabetic Cynomolgus Monkeys
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05663
Abstract: The prevalence of type 2 diabetes (T2DM) is increasing globally, creating essential demands for T2DM animal models for the study of disease pathogenesis, prevention, and therapy. A non-human primate model such as cynomolgus monkeys can… read more here.
Keywords: serum; cynomolgus; cynomolgus monkeys; analysis ... See more keywords
Uncovering of intraspecies macular heterogeneity in cynomolgus monkeys using hybrid machine learning optical coherence tomography image segmentation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99704-z
Abstract: The fovea is a depression in the center of the macula and is the site of the highest visual acuity. Optical coherence tomography (OCT) has contributed considerably in elucidating the pathologic changes in the fovea… read more here.
Keywords: optical coherence; image; machine learning; cynomolgus monkeys ... See more keywords