Worldwide Distribution of Cytochrome P450 Alleles: A Meta‐analysis of Population‐scale Sequencing Projects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.690
Abstract: Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic activity toward a plethora of clinically important medications. Thus, single nucleotide variants and copy number variations in CYP genes are major determinants of… read more here.
Keywords: drug; worldwide distribution; cytochrome p450; population ... See more keywords
β-Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3-L1 Cell Maturation into Adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Lipids"
DOI: 10.1002/lipd.12234
Abstract: Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β-cypermethrin (β-CYP)-mediated inhibition of the macrophages affects adipogenesis remain unknown.… read more here.
Keywords: raw 264; inhibitory effects; 264 cells; 3t3 cells ... See more keywords
Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23624
Abstract: Cypermethrin (CYP), a type II synthetic pyrethroid, is the most widely used insecticide worldwide. Inhalation of it may cause side effects. This study is aimed to examine potential protection of quercetin (QUE) which is a… read more here.
Keywords: stress; que; apoptosis; cyp ... See more keywords
Development of a cyclophosphamide stress test to predict resilience to aging in mice
Sign Up to like & getrecommendations! Published in 2020 at "GeroScience"
DOI: 10.1007/s11357-020-00222-z
Abstract: The concept of resilience, defined as the ability to recover from stress, is a potential platform to predict healthy aging. However, specific stress tests for resilience have not yet been fully established in humans so… read more here.
Keywords: age; resilience; stress; injection cyp ... See more keywords
Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-020-3216-2
Abstract: Objective To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome (IC/PBS). Methods The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial… read more here.
Keywords: bladder; group; myrrha; frankincense myrrha ... See more keywords
Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-021-01001-5
Abstract: Drug metabolism is a critical process for the removal of unwanted substances from the body. In humans, approximately 80% of oxidative metabolism and almost 50% of the overall elimination of commonly used drugs can be… read more here.
Keywords: metabolism; treatment outcomes; drug; cytochrome p450 ... See more keywords
Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological Reports"
DOI: 10.1007/s43440-020-00157-4
Abstract: Background Cytochrome P450 (CYP) enzymes are involved in the metabolism of many important endogenous substrates (steroids, melatonin), drugs and toxic xenobiotics. Their induction accelerates drug metabolism and elimination. The present study aimed at examining the… read more here.
Keywords: clozapine induce; clozapine; cyp3a4; levomepromazine clozapine ... See more keywords
Bioelectrodes for evaluating molecular therapeutic and toxicity properties
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Electrochemistry"
DOI: 10.1016/j.coelec.2019.09.004
Abstract: Abstract Recent progress on material designs merged with nanotechnology and biotechnology strategies has advanced studies of complex biological samples on electrodes for cytochrome P450 (CYP)–driven biocatalytic reactions (e.g. liver membrane fractions, cells, and various organ-specific CYP… read more here.
Keywords: bioelectrodes evaluating; therapeutic toxicity; molecular therapeutic; toxicity properties ... See more keywords
The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.03.109
Abstract: Previous studies have demonstrated that the anti-androgenic effects of cypermethrin (CYP) are associated with testosterone (T) - related signaling pathway. This study was to investigate the effects of CYP on mouse Sertoli cells (TM4) and… read more here.
Keywords: non classical; sertoli cells; pathway; anti androgenic ... See more keywords
Human CYP enzyme-activated clastogenicity of 2-ethylhexyl diphenyl phosphate (a flame retardant) in mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117527
Abstract: 2-Ethylhexyl diphenyl phosphate (EHDPP) is a common flame retardant and environmental pollutant, exposing humans with endocrinal disrupting potentials. Its mutagenicity, especially following metabolism, remains unclear. In this study, molecular docking analysis indicated that EHDPP was… read more here.
Keywords: cyp; diphenyl phosphate; flame retardant; human cyp ... See more keywords
Stereoisomeric selectivity in the endocrine-disrupting potential of cypermethrin using in vitro, in vivo, and in silico assays.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125389
Abstract: Despite the ubiquity of cypermethrin (CYP) stereoisomers in environment biota, the stereoisomeric selectivity of endocrine-disrupting potency of α-CYP, β-CYP, and θ-CYP has not been well studied. In this study, dual-luciferase reporter gene assays were adopted… read more here.
Keywords: selectivity endocrine; endocrine disrupting; cyp cyp; stereoisomeric selectivity ... See more keywords