Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01564
Abstract: Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like properties. Introducing a nitrogen atom into the aromatic portion of the tetrahydroisoquinoline ring led to several heterocyclic variants including the 5,6,7,8-tetrahydro-1,6-naphthyridine series, greatly reducing… read more here.
Keywords: drug like; cyp 2d6; tetrahydronaphthyridine; cxcr4 ... See more keywords
Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6.
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism letters"
DOI: 10.2174/1872312811666170407164631
Abstract: BACKGROUND Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, responsible for eliminating 25% of marketed drugs. We recently identified SHP as a negative regulator of CYP2D6 expression and showed that factors that alter SHP… read more here.
Keywords: p450 cyp; expression; cyp 2d6; cytochrome p450 ... See more keywords