Cross-species analysis of hepatic cytochrome P450 and transport protein expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02939-4
Abstract: Most drugs and xenobiotics are metabolized in the liver. Amongst others, different cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign compounds, and various transport proteins are engaged in the excretion of metabolites from… read more here.
Keywords: cross species; transport; p450; cytochrome p450 ... See more keywords
Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes
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DOI: 10.1039/d2ra06184h
Abstract: Gingerols, mainly [6]-gingerol (6G), [8]-gingerol (8G), and [10]-gingerol (10G), are the functional and specific pungent phytochemicals in ginger. However, poor oral bioavailability limits their applications owing to extensive metabolism. The present study aims to characterize… read more here.
Keywords: metabolism; gingerol gingerol; liver microsomes; cyp enzymes ... See more keywords
Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) – a comparison with the chemical inhibition method
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2017-0024
Abstract: Abstract Background: For estimation of fractions metabolized (fm) by different hepatic recombinant human CYP enzymes (rhCYP), calculation of inter-system extrapolation factors (ISEFs) has been proposed. Methods: ISEF values for CYP1A2, CYP2C19 and CYP3A4/5 were measured.… read more here.
Keywords: estimation; chemical inhibition; fractions metabolized; cyp enzymes ... See more keywords
Cytochrome P450 Structure, Function and Clinical Significance: A Review.
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DOI: 10.2174/1389450118666170125144557
Abstract: BACKGROUND The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies… read more here.
Keywords: drug; cyp enzymes; p450 structure; cytochrome p450 ... See more keywords
Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666220524121645
Abstract: Antiseizure medications and drugs for psychiatric diseases are frequently used in combination. In this context pharmacokinetic interactions between these drugs may occur. The vast majority of these interactions are primarily observed at a metabolic level… read more here.
Keywords: antiseizure medications; antiseizure psychiatric; drugs psychiatric; pharmacokinetic interactions ... See more keywords
Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.906027
Abstract: The cytochrome P450 (CYP) enzymes play a pivotal role in drug metabolism. LC-MS/MS-based targeting technology has been applied to the analysis of CYP enzymes, promoting drug development and drug-drug interaction studies. Rat is one of… read more here.
Keywords: cyp; liver microsomes; cytochrome p450; cyp enzymes ... See more keywords
Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity
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DOI: 10.3390/ijms20020347
Abstract: Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was… read more here.
Keywords: liver tumor; drug; hepg2 cells; expression ... See more keywords
Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes
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DOI: 10.3390/molecules27144482
Abstract: Curcumin and germacrone, natural products present in the Zingiberaceae family of plants, have several biological properties. Among these properties, the anti-NSCLC cancer action is noteworthy. In this paper, kinetics of the two compounds in rat… read more here.
Keywords: cyp enzymes; liver microsomes; curcumin germacrone; min ... See more keywords