Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
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DOI: 10.1021/acsmedchemlett.0c00004
Abstract: A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway modulation was demonstrated in vivo, which enabled evaluation of TDO as… read more here.
Keywords: cyp index; drug; tryptophan dioxygenase; design ... See more keywords