Structure-Guided Engineering of CYP109B4: From Monooxygenase to Peroxygenase for Selective Steroid Hydroxylation.
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DOI: 10.1021/acs.jafc.5c11530
Abstract: Cytochrome P450 CYP109B4 is a characterized 16β-steroid hydroxylase with significant potential in steroid drug biosynthesis, but its application is limited by reliance on costly coenzymes and complex electron transfer processes. To address this, we constructed… read more here.
Keywords: structure guided; guided engineering; cyp109b4; peroxygenase ... See more keywords