Abstract P233: Inhibition Of Aldosterone Synthesis In Non-human Primates By PB6440, The Novel Highly Selective And Potent CYP11B2 Inhibitor
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DOI: 10.1161/hyp.76.suppl_1.p233
Abstract: Aldosterone is an important mineralocorticoid responsible for fluid and electrolyte homeostasis produced by aldosterone synthase (CYP11B2). An aldosterone synthase inhibitor (ASI) may be a therapeu... read more here.
Keywords: inhibitor; aldosterone; cyp11b2; inhibition aldosterone ... See more keywords
Changes of the CYP11B2 Expressing Zona Glomerulosa in Human Adrenals From Birth to 40 Years of Age
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DOI: 10.1161/hypertensionaha.122.19052
Abstract: Background: Aldosterone synthase (CYP11B2) antibodies for immunohistochemistry, enables to visualize aldosterone-producing zona glomerulosa (ZG), aldosterone-producing micronodules, and aldosterone-producing adenomas. The architecture of the ZG differs in old versus young age but the evolution of the… read more here.
Keywords: aldosterone producing; area; zona glomerulosa; age ... See more keywords
Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case–control study
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DOI: 10.1186/s12920-022-01177-0
Abstract: Background Previous studies on the relationship between ACE I/D, ACE2 G8790A and CYP11B2-344T/C gene polymorphisms and essential hypertension (EH) were inconsistent. Moreover, few studies have reported the combined effect of these gene polymorphisms and noise… read more here.
Keywords: gene polymorphisms; ace ace2; gene; essential hypertension ... See more keywords
SUN-043 Epigenetic Regulation of Aldosterone Synthase Gene by Potassium
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DOI: 10.1210/js.2019-sun-043
Abstract: Abstract Purpose: DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We reported that angiotensin II could change the DNA methylation status… read more here.
Keywords: demethylation; potassium; methylation; dna methylation ... See more keywords
Ectopic localization of CYP11B1 and CYP11B2-expressing cells in the normal human adrenal gland
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DOI: 10.1371/journal.pone.0279682
Abstract: The sharp line of demarcation between zona glomerulosa (ZG) and zona fasciculata (ZF) has been recently challenged suggesting that this interface is no longer a compartment boundary. We have used immunohistochemical analyses to study the… read more here.
Keywords: cyp11b1; expressing cells; cyp11b2; human adrenal ... See more keywords
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma.
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DOI: 10.1530/eje-18-0882
Abstract: Objective The pathophysiology of aldosterone-producing adenomas (APAs) has been intensively investigated using genetic and epigenetic approaches. However, the role of miRNAs in APA is not fully understood. The present study profiled miRNAs in APAs as… read more here.
Keywords: expression; mirnas apa; involvement; cyp11b2 ... See more keywords
Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1
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DOI: 10.3390/ijms24065782
Abstract: Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene expression… read more here.
Keywords: aldosterone; cyp11b1; control; expression ... See more keywords