Variants in the CYP19A1 gene can affect in vitro embryo production traits in cattle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-018-1320-4
Abstract: PurposeThis study aimed to associate DNA variants in promoter and exon flanking regions of the CYP19A1 gene with in vitro embryo production traits in cattle. The role of transcription factor binding sites created or lost… read more here.
Keywords: embryo production; production traits; production; vitro embryo ... See more keywords
The transcription factor SMAD4 and miR-10b contribute to E2 release and cell apoptosis in ovarian granulosa cells by targeting CYP19A1
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.04.012
Abstract: The cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene, encodes aromatase, a key enzyme in estradiol (E2) synthesis, and is down-regulated during porcine follicular atresia. However, its role in and the mechanism of… read more here.
Keywords: granulosa cells; mir 10b; cell apoptosis; factor ... See more keywords
Organochlorine pesticide dieldrin upregulate proximal promoter (PII) driven CYP19A1 gene expression and increases estrogen production in granulosa cells.
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2021.10.009
Abstract: Organochlorine pesticides are highly persistent environmental pollutants, generally shown to act through estrogen receptor alpha and alter estrogen biosynthesis. However, the molecular mechanism of regulation of estrogen biosynthesis by these pesticides is not clear. Estrogen… read more here.
Keywords: dieldrin; expression; promoter; gene ... See more keywords