CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.47868
Abstract: Key Points Question Does CYP1A2 genotype modify the association between coffee intake and kidney dysfunction? Findings In this cohort study involving a 7.5-year follow-up of 1180 untreated participants with stage 1 hypertension from the Hypertension… read more here.
Keywords: coffee; kidney dysfunction; coffee intake; intake kidney ... See more keywords
Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation–Positive Malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.788
Abstract: This phase 1 open‐label, multicenter, 3‐period, fixed‐sequence study evaluated the effect of multiple doses of vemurafenib on the pharmacokinetics of 1 dose of tizanidine, a probe CYP1A2 substrate, in patients with BRAFV600 mutation–positive metastatic malignancy.… read more here.
Keywords: period; dose tizanidine; drug; vemurafenib ... See more keywords
Prenatal exposure to PCBs in Cyp1a2 knock‐out mice interferes with F1 fertility, impairs long‐term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3751
Abstract: Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. PCB toxicity depends on the… read more here.
Keywords: acoustic startle; exposure; pcbs; pcb ... See more keywords
Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen‐induced metabolic activation and hepatotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7604
Abstract: Psoralen and isopsoralen are the pharmacologically important but hepatotoxic components in Psoraleae Fructus. The purpose of this study was to reveal the underlying mechanism of psoralen/isopsoralen‐induced hepatotoxicity. Initially, we applied integrated analyses of transcriptomic and… read more here.
Keywords: isopsoralen induced; psoralen isopsoralen; role cyp1a2; metabolic activation ... See more keywords
Time effect of rutaecarpine on caffeine pharmacokinetics in rats
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101121
Abstract: Rutaecarpine is reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to enhance the CYP1A2-dependent removal of caffeine from blood so that people can… read more here.
Keywords: effect rutaecarpine; caffeine; time; cyp1a2 ... See more keywords
Phe-125 and Phe-226 of pig cytochrome P450 1A2 stabilize the binding of aflatoxin B1 and 7-ethoxyresorufin through the key CH/π interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.031
Abstract: Cytochrome P450 1A2 (CYP1A2) plays important roles in the metabolism of many planar and aromatic drugs and also contributes to the bioactivation of aflatoxin B1 (AFB1) in vivo. To date, the structural basis for CYP1A2's… read more here.
Keywords: pig; phe 125; phe 226; phe ... See more keywords
Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.01.008
Abstract: HighlightsGenetic variation in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) alter sensitivity to developmental PCB exposure.PCB‐treated high‐affinity Ahrb mice had greater deficits in motor function tests associated with nigrostriatal pathways.PCB‐treated Cyp1a2(−/−) knockout mice… read more here.
Keywords: exposure; pcb; motor; mice ... See more keywords
&bgr;‐Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2‐knockout mice
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.11.017
Abstract: &NA; Exposure to supraphysiological concentrations of oxygen (hyperoxia) leads to bronchopulmonary dysplasia (BPD), one of the most common pulmonary morbidities in preterm neonates, which is more prevalent in males than females. Beta‐naphthoflavone (BNF) is protective… read more here.
Keywords: treatment; mice; lung injury; cyp1a2 ... See more keywords
The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level.
Sign Up to like & getrecommendations! Published in 2018 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.03.002
Abstract: This study aimed to investigate whether the influence of CYP1A2 genotype in the blood pressure (BP) response to caffeine ingestion was affected by physical activity status and habitual caffeine consumption. Thirty-seven participants (19-50 years old) took… read more here.
Keywords: physical activity; caffeine; caffeine ingestion; cyp1a2 ... See more keywords
Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp.
Sign Up to like & getrecommendations! Published in 2021 at "Planta medica"
DOI: 10.1055/a-1557-2113
Abstract: Bulbine natalensis, an emerging medicinal herb on the global market with androgenic properties, is often formulated in dietary supplements that promote perceived sexual enhancement. However, to date, comprehensive safety studies of B. natalensis are lacking,… read more here.
Keywords: bulbine natalensis; cyp2b6; activity; bulbine ... See more keywords
Multi-omics analysis revealed the role of CYP1A2 in the induction of mechanical allodynia in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1151340
Abstract: Background: Mechanical allodynia (MA) is one of the leading clinical symptoms of painful diabetic peripheral neuropathy (PDPN), which is a primary reason for non-traumatic amputations, foot ulceration, and gait abnormalities in patients with diabetes. However,… read more here.
Keywords: microscopy; mechanical allodynia; group; analysis ... See more keywords