Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2943-y
Abstract: Numerous experimental studies have demonstrated the role of cytochrome P450 1B1 (CYP1B1) and its associated mid-chain hydroxyeicosatetraenoic acids (mid-chain HETEs) metabolite in the pathogenesis of cardiac hypertrophy. However, the ability of isoproterenol (ISO) to induce…
read more here.
Keywords:
cyp1b1;
mid chain;
mid;
cardiac hypertrophy ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04790-y
Abstract: Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes…
read more here.
Keywords:
cyp1b1;
haplotypes cyp1b1;
afro caribbean;
ccdc57 genes ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.016
Abstract: The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones.…
read more here.
Keywords:
cyp1b1;
cyp1b1 inhibitors;
ic50 values;
cisplatin resistance ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102142
Abstract: To determine the roles of nuclear localization of pro-caspase-1 in human aortic endothelial cells (HAECs) activated by proatherogenic lipid lysophosphatidylcholine (LPC), we examined cytosolic and nuclear localization of pro-caspase-1, identified nuclear export signal (NES) in…
read more here.
Keywords:
cyp1b1;
caspase;
lpc;
inhibitor ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01306
Abstract: As a promising therapeutic target for cancer, CYP1B1 is overexpressed in Taxol-resistant A549 cells; however, its role in drug resistance still remains unclear. Bioinformatic analysis data indicated that CYP1B1 was closely correlated with AKT/ERK1/2 and…
read more here.
Keywords:
taxol resistance;
migration invasion;
cyp1b1;
resistance ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra00465j
Abstract: The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy. Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo[h]quinolone derivatives were designed, synthesized and evaluated as selective CYP1B1 inhibitors. Compared with…
read more here.
Keywords:
cyp1b1;
cyp1b1 inhibitors;
selective cyp1b1;
arylbenzo quinolone ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
2
Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2756986
Abstract: Objective Increasing numbers of studies have proved that m6A methylation plays crucial roles in different cancers. However, how lncRNA regulates m6A methylation and participates in acute myeloid leukemia (AML) remains unclear. Therefore, this study aims…
read more here.
Keywords:
expression;
methylation;
aml;
cyp1b1 ... See more keywords
Sign Up to like & get
recommendations!
3
Published in 2023 at "Cerebrovascular diseases"
DOI: 10.1159/000526918
Abstract: INTRODUCTION Ischemic stroke (IS) is an extremely complex disease caused by the combined action of multiple environmental and genetic factors. CYP1B1 is a member of the cytochrome P450 protein family, and it is an important…
read more here.
Keywords:
genetic variants;
chinese han;
cyp1b1;
han population ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230119103914
Abstract: CYP1B1 plays an essential role in cancer's pathogenesis since it activates procarcinogens. Significantly, this enzyme catalyzes the hydroxylation of 17β-estradiol, leading to carcinogenic metabolites involved in carcinogenesis and cancer progression. Therefore, the inhibition of CYP1B1…
read more here.
Keywords:
promising target;
cyp1b1;
cyp1b1 promising;
drug ... See more keywords
Photo by nci from unsplash
Sign Up to like & get
recommendations!
1
Published in 2022 at "Cancers"
DOI: 10.3390/cancers14225641
Abstract: Simple Summary Cytochrome P450 Family 1 Subfamily B Member 1 (CYP1B1) is a critical metabolic enzyme of melatonin. Although melatonin has been identified to exhibit tumor suppressing activity, the role and mechanism of the clinical…
read more here.
Keywords:
subtype tumor;
cyp1b1;
tumor;
cancer ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032420
Abstract: Cytochrome P450 (CYP) 1B1 is a heme-containing monooxygenase found mainly in extrahepatic tissues, including the retina. CYP1B1 substrates include exogenous aromatic hydrocarbons, such as dioxins, and endogenous bioactive compounds, including 17β-estradiol (E2) and arachidonic acid.…
read more here.
Keywords:
iron;
oxidative stress;
cyp1b1;
expression ... See more keywords