The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2943-y
Abstract: Numerous experimental studies have demonstrated the role of cytochrome P450 1B1 (CYP1B1) and its associated mid-chain hydroxyeicosatetraenoic acids (mid-chain HETEs) metabolite in the pathogenesis of cardiac hypertrophy. However, the ability of isoproterenol (ISO) to induce… read more here.
Keywords: cyp1b1; mid chain; mid; cardiac hypertrophy ... See more keywords
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04790-y
Abstract: Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes… read more here.
Keywords: cyp1b1; haplotypes cyp1b1; afro caribbean; ccdc57 genes ... See more keywords
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.016
Abstract: The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones.… read more here.
Keywords: cyp1b1; cyp1b1 inhibitors; ic50 values; cisplatin resistance ... See more keywords
Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102142
Abstract: To determine the roles of nuclear localization of pro-caspase-1 in human aortic endothelial cells (HAECs) activated by proatherogenic lipid lysophosphatidylcholine (LPC), we examined cytosolic and nuclear localization of pro-caspase-1, identified nuclear export signal (NES) in… read more here.
Keywords: cyp1b1; caspase; lpc; inhibitor ... See more keywords
Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01306
Abstract: As a promising therapeutic target for cancer, CYP1B1 is overexpressed in Taxol-resistant A549 cells; however, its role in drug resistance still remains unclear. Bioinformatic analysis data indicated that CYP1B1 was closely correlated with AKT/ERK1/2 and… read more here.
Keywords: taxol resistance; migration invasion; cyp1b1; resistance ... See more keywords
The AKR1C1–CYP1B1–cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01407-1
Abstract: Extrahepatic cholangiocarcinoma (ECC), a highly malignant type of cancer with increasing incidence, has a poor prognosis due to limited treatment options. Based on genomic analysis of ECC patient samples, here we report that aldo-keto reductase… read more here.
Keywords: akr1c1 cyp1b1; ecc; ferroptosis; extrahepatic cholangiocarcinoma ... See more keywords
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62762-2
Abstract: Coxiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms. Long non-coding RNAs (lncRNAs) are crucial yet underexplored regulators of inflammation, particularly in Cb… read more here.
Keywords: cyp1b1; coxiella burnetii; cyp1b1 as1;
Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors
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DOI: 10.1039/c8ra00465j
Abstract: The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy. Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo[h]quinolone derivatives were designed, synthesized and evaluated as selective CYP1B1 inhibitors. Compared with… read more here.
Keywords: cyp1b1; cyp1b1 inhibitors; selective cyp1b1; arylbenzo quinolone ... See more keywords
Design and synthesis of new alfa-naphthoflavanones as potent and selective CYP1B1 inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Natural Product Research"
DOI: 10.1080/14786419.2024.2375751
Abstract: Abstract Natural Flavanones are abundant in human diet and a few of them exhibited chemopreventive effects against xenobiotic procarcinogens through the inhibition of tumour specific CYP1B1 enzyme. Herein, a series of new alfa-naphthoflavanones were synthesised… read more here.
Keywords: design synthesis; alfa naphthoflavanones; naphthoflavanones potent; new alfa ... See more keywords
Quantum chemical analysis and biochemical evaluation of the inhibitory activity of puerarin on CYP1B1 enzyme
Sign Up to like & getrecommendations! Published in 2024 at "Chemistry Letters"
DOI: 10.1093/chemle/upae160
Abstract: The inhibitory activity of puerarin on the CYP1B1 enzyme was evaluated by the 7-ethoxyresorufin O-dealkylation method. At the same time, the density functional theory algorithm, molecular docking, and molecular dynamics simulations were used to verify… read more here.
Keywords: cyp1b1; puerarin cyp1b1; cyp1b1 enzyme; activity puerarin ... See more keywords
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
Sign Up to like & getrecommendations! Published in 2024 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adk8446
Abstract: Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase cytochrome P450 1B1 (CYP1B1) was elevated in human and mouse fibrotic… read more here.
Keywords: inhibition; liver fibrosis; activation; hepatic stellate ... See more keywords