Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.
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DOI: 10.1016/j.ejmech.2017.02.016
Abstract: The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones.… read more here.
Keywords: cyp1b1; cyp1b1 inhibitors; ic50 values; cisplatin resistance ... See more keywords
Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors
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DOI: 10.1039/c8ra00465j
Abstract: The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy. Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo[h]quinolone derivatives were designed, synthesized and evaluated as selective CYP1B1 inhibitors. Compared with… read more here.
Keywords: cyp1b1; cyp1b1 inhibitors; selective cyp1b1; arylbenzo quinolone ... See more keywords
Identification of potential benzoxazolinone as CYP1B1 inhibitors via molecular docking, dynamics, waterswap, and In vitro analysis
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DOI: 10.1039/d3nj01138k
Abstract: Overexpression of Cytochrome P450 1B1 in malignancies is accountable for the biotransformation-based inactivation of various chemotherapeutics such as docetaxel, paclitaxel, cisplatin, and tamoxifen. Additionally, it also plays a major role... read more here.
Keywords: inhibitors via; benzoxazolinone cyp1b1; identification potential; potential benzoxazolinone ... See more keywords