Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2'-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and Whites.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00413
Abstract: Smoking intensity varies across smokers and is influenced by individual variability in the metabolism of nicotine, the major addictive agent in tobacco. Therefore, lung cancer risk, which varies by racial ethnic group, is influenced by… read more here.
Keywords: oxidation; nicotine oxidation; cyp2a6; japanese americans ... See more keywords
Mining of molecular insights of CYP2A6 and its variants complex with coumarin (CYP2A6*-coumarin) using molecular dynamics simulation
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DOI: 10.1080/07391102.2022.2062785
Abstract: Abstract CYP2A6 is a very important enzyme that plays a crucial role in nicotine compounds and is responsible for the metabolism of more than 3% drugs of total metabolized drugs by the CYP family and… read more here.
Keywords: cyp2a6 cyp2a6; cyp2a6; cyp2a6 coumarin; coumarin ... See more keywords
CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study
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DOI: 10.1093/carcin/bgx012
Abstract: Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolism of nicotine and the tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case-control study of… read more here.
Keywords: risk lung; lung cancer; cyp2a6; lung ... See more keywords
Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke.
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DOI: 10.1111/cts.13115
Abstract: Prevalence of smoking is higher in Alaska Native and American Indian (ANAI) populations living in Alaska than the general US population. Genetic factors contribute to smoking and cessation rates. The objective of this study was… read more here.
Keywords: cyp2a6; genotype; anai populations; association cyp2a6 ... See more keywords
Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population
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DOI: 10.1186/s12885-018-4342-5
Abstract: BackgroundSeveral studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of… read more here.
Keywords: cancer; egyptian population; cyp2a6; lung cancer ... See more keywords
Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study
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DOI: 10.1186/s12885-020-6663-4
Abstract: Background CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). The whole gene deletion of CYP2A6 (CYP2A6*4) is prevalent in East Asian… read more here.
Keywords: cyp2a6; cyp2a6 deletion; association; deletion ... See more keywords
CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response
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DOI: 10.3389/fphar.2022.943200
Abstract: Background: Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing… read more here.
Keywords: cyp2a6; rate; drug response; drug ... See more keywords
Variation in CYP2A6 Activity and Personalized Medicine
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DOI: 10.3390/jpm7040018
Abstract: The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant substrates, including nicotine—the primary psychoactive component in cigarette smoke. The gene that encodes the CYP2A6 enzyme is highly polymorphic, resulting in extensive interindividual variation in… read more here.
Keywords: medicine; cyp2a6; cyp2a6 enzyme; variation cyp2a6 ... See more keywords
Quantitative structure-activity relationship to elucidate human CYP2A6 inhibition by organosulfur compounds
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DOI: 10.5599/admet.678
Abstract: CYP2A6 is a human enzyme responsible for the metabolic elimination of nicotine, and it is also involved in the activation of procarcinogenic nitrosamines, especially those present in tobacco smoke. Several investigations have reported that reducing… read more here.
Keywords: cyp2a6; quantitative structure; organosulfur compounds; activity relationship ... See more keywords