Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.
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DOI: 10.1021/acs.est.8b05250
Abstract: Exposure to chiral polychlorinated biphenyls (PCBs) has been associated with neurodevelopmental disorders. Their hydroxylated metabolites (OH-PCBs) are also potentially toxic to the developing human brain; however, the formation of OH-PCBs by human cytochrome P450 (P450)… read more here.
Keywords: hydroxylated metabolites; cyp2a6 cyp2b6; polychlorinated biphenyls; cyp2e1 ... See more keywords