Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
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DOI: 10.1124/dmd.119.086348
Abstract: Efavirenz (more specifically the S-enantiomer) is a cornerstone antiretroviral therapy for treatment of HIV infection. The major primary metabolite is S-8-hydroxyefavirenz, which does not have antiretroviral activity but is neurotoxic. Cytochrome P450 2B6 (CYP2B6) is… read more here.
Keywords: cyp2b6; efavirenz hydroxylation; cyp2b6 variants; efavirenz metabolism ... See more keywords
Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants
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DOI: 10.1124/dmd.119.090407
Abstract: Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by CYP2B6. The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion… read more here.
Keywords: bupropion hydroxylation; cyp2b6; p450; cyp2b6 cyp2b6 ... See more keywords