Physiologically based pharmacokinetic modelling to determine the impact of CYP2B6 genotype on efavirenz exposure in children, mothers and breastfeeding infants.
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DOI: 10.1002/cpt.2912
Abstract: The antiretroviral drug efavirenz remains widely used in children and mothers during breastfeeding in tuberculosis-endemic areas. Evaluating the safety of efavirenz during breastfeeding requires an understanding of its pharmacokinetics in breast milk, its exposure in… read more here.
Keywords: efavirenz; mothers breastfeeding; breastfeeding infants; cyp2b6 ... See more keywords