Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
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DOI: 10.1002/cpt.2903
Abstract: Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (SNRIs; i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with… read more here.
Keywords: htr2a; cyp2d6 cyp2c19; cyp2c19; cyp2c19 cyp2b6 ... See more keywords
Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel
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DOI: 10.1007/s00228-017-2401-5
Abstract: PurposeBleeding is one of the possible adverse events during clopidogrel therapy. The CYP2C19 gene is the most significant genetic factor which influences response to clopidogrel treatment. We aimed to examine the contribution of the CYP2C19… read more here.
Keywords: cyp2c19; clopidogrel; rs11568732; rs11568732 variant ... See more keywords
Dual therapy with clopidogrel and aspirin prevents early neurological deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles
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DOI: 10.1007/s00228-018-2468-7
Abstract: PurposeTo investigate the associations between CYP2C19 genotypes and early neurological deterioration (END), and to carry out a stratified analysis of the effectiveness of clopidogrel alone and dual antiplatelet therapy with clopidogrel and aspirin for prevention… read more here.
Keywords: reduced function; clopidogrel; end; therapy ... See more keywords
Letter to the Editor in Response to “Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally”
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DOI: 10.1007/s12325-019-01195-y
Abstract: First available online on September 3, 2019 in Advances in Therapy, Zubiaur et al. [1] suggested that the CYP2C19 phenotype may help explain some of the variability in serum progesterone concentrations when taken orally or… read more here.
Keywords: metabolism; steroid hormones; zubiaur; cyp2c19 ... See more keywords
Author’s Response to: ‘Letter to the Editor in Response to: “Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally”’
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DOI: 10.1007/s12325-019-01196-x
Abstract: We are pleased to reply to Lazorwitz et al. [1] letter response in regard to our manuscript published in Advances in Therapy on September 2019 [2]. First, we commend the efforts of Lazorwitz A. and… read more here.
Keywords: response; metabolism; letter; cyp2c19 ... See more keywords
CYP2C19 Metabolizer Status Does Not Influence the Safety or Efficacy of Pentamidine
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DOI: 10.1016/j.bbmt.2019.12.596
Abstract: Background Pneumocystis jirovecii (PJP) infections are a significant cause of morbidity and mortality in recipients of hematopoietic cell transplantations (HCT), and PJP prophylaxis is a standard of care. The gold standard for PJP prophylaxis is… read more here.
Keywords: metabolizer status; cyp2c19 metabolizer; metabolizer; function ... See more keywords
48 META-ANALYSIS OF CYP2C19 ASSOCIATION WITH EFFICACY AND SIDE EFFECTS OF CITALOPRAM AND ESCITALOPRAM USING DATA FROM GENOME-WIDE ASSOCIATION STUDIES
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DOI: 10.1016/j.euroneuro.2017.08.049
Abstract: Background Major Depressive Disorder (MDD) is a leading cause of disability-adjusted life years worldwide. Genetic polymorphisms may have the potential to guide antidepressant treatment to increase current remission rates. Cytochrome P450 (CYP450) enzymes are responsible… read more here.
Keywords: side effects; association; citalopram escitalopram; cyp2c19 ... See more keywords
P.1.019 Phenazepam's safety pharmacogenetic study results: influence of CYP2C9, CYP3A5, CYP2C19, ABCB1 and CYP3A4/5 isoenzymes' activity
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DOI: 10.1016/j.euroneuro.2017.12.037
Abstract: Introduction Bromdihydrochlorphenylbenzodiazepine (Phenazepam) is the Russian original benzodiazepine, which was widely prescribed in post-Soviet countries. The chemical structure is close to clonazepam [1]. Alcohol withdrawal syndrome is one from the most frequent indications for Phenazepam.… read more here.
Keywords: safety; cyp3a4 activity; cyp3a4; cyp2c19 ... See more keywords
CYP2C19 genotype-directed P2Y12 inhibitor antiplatelet therapy normalizes risk for major adverse cardiovascular events after percutaneous coronary intervention
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DOI: 10.1016/j.ihj.2021.03.004
Abstract: Objective To study the use of CYP2C19 genotyping to guide P2Y12 inhibitor selection to maximize efficacy, and attenuate risk in appropriate patients who underwent PCI for CAD. Methods We performed a retrospective analysis of 868… read more here.
Keywords: cyp2c19; risk; p2y12 inhibitor; cyp2c19 genotype ... See more keywords
CYP2C19 activity and cardiovascular risk factors in patients with an acute coronary syndrome.
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DOI: 10.1016/j.medcli.2017.02.035
Abstract: INTRODUCTION CYP2C19 is a major isoform of cytochrome P450 that metabolizes a number of drugs and is involved in the glucocorticoids synthesis. CYP2C19 polymorphisms have been associated with the genetic risk for type 2 diabetes.… read more here.
Keywords: risk; patients acute; acute coronary; cyp2c19 ... See more keywords
CYP2C19 STATUS AND OUTCOMES IN THE EUCLID TRIAL
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DOI: 10.1016/s0735-1097(18)32628-7
Abstract: Cytochrome P450 2C19 (CYP2C19) is a hepatic enzyme involved in metabolism of clopidogrel to its active metabolite. Polymorphisms with 2 loss-of-function (LOF) alleles lead to poor metabolism of clopidogrel, but little is known about the… read more here.
Keywords: outcomes euclid; cardiology; cyp2c19 status; status outcomes ... See more keywords