CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal
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DOI: 10.3389/fmed.2022.854280
Abstract: To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient's individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors… read more here.
Keywords: pump inhibitors; proton pump; stress ulcer; cyp2c19 gene ... See more keywords
From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19
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DOI: 10.3389/fphar.2023.1076574
Abstract: Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide… read more here.
Keywords: allele tools; cyp2c19 gene; gene dose; read sequencing ... See more keywords
Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
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DOI: 10.3390/jpm13020285
Abstract: Diazepam is a benzodiazepine widely prescribed for the management of patients with severe alcohol withdrawal syndrome to prevent agitation, withdrawal seizures, and delirium tremens. Despite standard dosing of diazepam, a subset of patients experience refractory… read more here.
Keywords: alcohol withdrawal; withdrawal; cyp2c19 gene; withdrawal syndrome ... See more keywords
Electrochemical Biosensor for Detection of the CYP2C19*2 Allele Based on Exonuclease Ⅲ
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DOI: 10.3390/mi14030541
Abstract: Currently, the therapeutic effect of clopidogrel differs considerably among individuals and is thought to be closely related to the genetic polymorphism of CYP2C19. The CYP2C19*2 gene can reduce the antiplatelet aggregation effect of clopidogrel, which… read more here.
Keywords: cyp2c19; detection cyp2c19; cyp2c19 gene; detection ... See more keywords