CYP2C19 Genotype-Guided Antiplatelet Therapy Among Asian Patients with Ischaemic Stroke
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DOI: 10.1007/s40261-020-00985-5
Abstract: We read with interest the cost-effectiveness study by Narasimhalu et al. [1], which evaluated the cost effectiveness of CYP2C19 genotype-guided antiplatelet therapy in an Asian population of patients presenting with acute ischaemic stroke with the… read more here.
Keywords: cyp2c19 genotype; antiplatelet therapy; genotype; guided antiplatelet ... See more keywords
CYP2C19 genotype-directed P2Y12 inhibitor antiplatelet therapy normalizes risk for major adverse cardiovascular events after percutaneous coronary intervention
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DOI: 10.1016/j.ihj.2021.03.004
Abstract: Objective To study the use of CYP2C19 genotyping to guide P2Y12 inhibitor selection to maximize efficacy, and attenuate risk in appropriate patients who underwent PCI for CAD. Methods We performed a retrospective analysis of 868… read more here.
Keywords: cyp2c19; risk; p2y12 inhibitor; cyp2c19 genotype ... See more keywords
BEDSIDE TESTING OF CYP2C19 GENOTYPE TO GUIDE ANTIPLATELET THERAPY: IMPLEMENTATION IN THE CATHETERIZATION LABORATORY
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DOI: 10.1016/s0735-1097(18)31743-1
Abstract: Although FDA recommended pharmacogenetic testing and alternative antiplatelet agents in CYP2C19 loss-of-function(LoF) allele carriers in patients treated with clopidogrel, implementation in practice has been minimal. Appropriate P2Y12 receptor antagonist therapy following PCI based on bedside read more here.
Keywords: cyp2c19 genotype; implementation; antiplatelet; bedside testing ... See more keywords
Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms
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DOI: 10.1136/svn-2022-001720
Abstract: Background and purpose Light transmission aggregometry (LTA) and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial aneurysms. The aim of this study was to… read more here.
Keywords: cyp2c19 genotype; ischaemic events; adp mpa; ischaemic complications ... See more keywords
Clopidogrel Versus Ticagrelor or Prasugrel After Primary Percutaneous Coronary Intervention According to CYP2C19 Genotype
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DOI: 10.1161/circinterventions.120.009434
Abstract: Supplemental Digital Content is available in the text. Background: Guidelines favor ticagrelor or prasugrel over clopidogrel in patients with myocardial infarction. However, the POPular Genetics trial (Patient Outcome After Primary Percutaneous Coronary Intervention [PCI]) showed… read more here.
Keywords: ticagrelor prasugrel; prasugrel; clopidogrel; cyp2c19 genotype ... See more keywords
The effect of CYP2C19 genotype-guided antiplatelet therapy on outcomes of selective percutaneous coronary intervention patients: an observational study.
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DOI: 10.2217/pme-2018-0087
Abstract: Aim: To observe if personalized antiplatelet therapy according to the CYP2C19 phenotype can improve the outcomes of patients receiving selective percutaneous coronary intervention (PCI). Methods: In this observational study, 677 Chinese patients undergoing selective PCI… read more here.
Keywords: therapy; antiplatelet therapy; guided antiplatelet; cyp2c19 genotype ... See more keywords
CYP2C19 genotype and platelet aggregation test-guided dual antiplatelet therapy after off-pump coronary artery bypass grafting: A retrospective cohort study
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DOI: 10.3389/fcvm.2022.1023004
Abstract: Background Dual antiplatelet therapy (DAPT) is recommended in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB). Clopidogrel is less effective among patients with loss-of-function (LoF) of CYP2C19 alleles, while ticagrelor has direct effects on… read more here.
Keywords: cyp2c19 genotype; pagt; aggregation test; cyp2c19 ... See more keywords