The frequency of CYP2C19 loss-of-function variants in patients with non-cardioembolic ischemic stroke or transient ischemic attack in the Dutch population.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebrovascular diseases"
DOI: 10.1159/000529892
Abstract: INTRODUCTION The CYP2C19 enzyme converts clopidogrel into an active metabolite. Carriers of CYP2C19 loss-of-function (LOF) variants with a history of ischemic stroke or transient ischemic attack (TIA) using clopidogrel may have a higher risk of… read more here.
Keywords: cyp2c19 lof; lof variants; stroke; stroke tia ... See more keywords
CYP2C19 polymorphisms and clopidogrel efficacy in the secondary prevention of ischemic stroke: a retrospective observational study.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of palliative medicine"
DOI: 10.21037/apm-21-2905
Abstract: BACKGROUND The relationship between cytochrome P450 2C19 (CYP2C19) polymorphisms and clopidogrel efficacy in patients with percutaneous coronary intervention (PCI) has been widely studied. However, the relationship between CYP2C19 polymorphisms and the response to clopidogrel in… read more here.
Keywords: ischemic stroke; lof alleles; cyp2c19 polymorphisms; cyp2c19 lof ... See more keywords