CYP2C19 polymorphisms and outcomes of Escitalopram treatment in Brazilians with major depression
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DOI: 10.1016/j.heliyon.2020.e04015
Abstract: Escitalopram (ESC), a selective serotonin reuptake inhibitor indicated for the treatment of depression and anxiety disorders, is primarily metabolized by cytochrome P450 (CYP) 2C19, which is a highly polymorphic enzyme known to cause inter-individual differences… read more here.
Keywords: depression; mirtazapine bupropion; treatment; polymorphisms outcomes ... See more keywords
Genetic variability in stroke patients: CYP2C19 polymorphisms unraveled
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DOI: 10.1186/s12920-024-01886-8
Abstract: Objective To study the distribution characteristics of CYP2C19 polymorphisms in patients suffering from stroke in Han Chinese patients. Method PCR and DNA microarray chip technology were used to detect the CYP2C19 genotype of 549 patients… read more here.
Keywords: patients stroke; stroke; cyp2c19 polymorphisms; type ... See more keywords
Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20165660
Abstract: Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture… read more here.
Keywords: clopidogrel hyporesponsiveness; clopidogrel; pon1; responsiveness ... See more keywords
CYP2C19 polymorphisms and clopidogrel efficacy in the secondary prevention of ischemic stroke: a retrospective observational study.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of palliative medicine"
DOI: 10.21037/apm-21-2905
Abstract: BACKGROUND The relationship between cytochrome P450 2C19 (CYP2C19) polymorphisms and clopidogrel efficacy in patients with percutaneous coronary intervention (PCI) has been widely studied. However, the relationship between CYP2C19 polymorphisms and the response to clopidogrel in… read more here.
Keywords: ischemic stroke; lof alleles; cyp2c19 polymorphisms; cyp2c19 lof ... See more keywords