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   Articles with "cyp2c8" as a keyword



Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

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recommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"

DOI: 10.1002/cpt.807

Abstract: Our recent studies have shown that chronic kidney disease (CKD) affects the pharmacokinetics (PKs) of cytochrome P450 (CYP)2D6‐metabolized drugs, whereas effects were less evident on CYP3A4/5. Therefore, the effect of CKD on the disposition of… read more here.

Keywords: cyp2c9; cyp2c8; effect; cyp2c9 cyp2c19 ... See more keywords

Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity

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recommendations! Published in 2022 at "Xenobiotica"

DOI: 10.1080/00498254.2022.2083531

Abstract: Abstract This study aimed to assess the effects of total flavonoid extracts (TFDG) and the monomers of Daphne genkwa on the CYP2C8 activity in vitro and in vivo. The 50% inhibitory concentration (IC50) values were… read more here.

Keywords: flavonoid extracts; effects total; cyp2c8 activity; cyp2c8 ... See more keywords

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages

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recommendations! Published in 2017 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.116.074583

Abstract: Predicting age-specific metabolism is important for evaluating age-related drug and chemical sensitivity. Multiple cytochrome P450s and carboxylesterase enzymes are responsible for human pyrethroid metabolism. Complete ontogeny data for each enzyme are needed to support in… read more here.

Keywords: age dependent; age; cyp2c8; cyp2c8 cyp1a2 ... See more keywords

CYP2C8-Mediated Drug–Drug Interactions and the Factors Influencing the Interaction Magnitude

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recommendations! Published in 2025 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s541536

Abstract: Background Older adults often have multiple morbidities that may lead to polypharmacy. Cytochrome P450 (CYP) 2C8 has shown significant contributions in the metabolism of various medications; however, its related drug–drug interactions (DDIs) appear to be… read more here.

Keywords: drug interactions; cyp2c8; drug; magnitude ... See more keywords