Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.807
Abstract: Our recent studies have shown that chronic kidney disease (CKD) affects the pharmacokinetics (PKs) of cytochrome P450 (CYP)2D6‐metabolized drugs, whereas effects were less evident on CYP3A4/5. Therefore, the effect of CKD on the disposition of… read more here.
Keywords: cyp2c9; cyp2c8; effect; cyp2c9 cyp2c19 ... See more keywords
In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2404-2
Abstract: PurposeThe purpose of the study is to investigate the enzyme(s) responsible for siponimod metabolism and to predict the inhibitory effects of fluconazole as well as the impact of cytochrome P450 (CYP) 2C9 genetic polymorphism on… read more here.
Keywords: metabolism; genetic polymorphism; siponimod metabolism; cyp2c9 ... See more keywords
Massively parallel characterization of CYP2C9 variant enzyme activity and abundance.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.07.001
Abstract: CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed… read more here.
Keywords: cyp2c9; massively parallel; abundance massively; enzyme ... See more keywords
An identification and functional evaluation of a novel CYP2C9 variant CYP2C9*62.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109168
Abstract: Warfarin is the most commonly used anticoagulant in the clinical treatment of thromboembolic diseases. The dose of warfarin varies significantly within populations, and the dose is closely related to the genetic polymorphisms of the CYP2C9… read more here.
Keywords: functional evaluation; evaluation novel; identification functional; cyp2c9 ... See more keywords
Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00098
Abstract: Methysticin is one of the naturally occurring bioactive constituents extracted from Piper methysticum Forst. In the present study, we intended to investigate the inhibitory effect of methysticin on cytochrome P450 (P450) enzymes. Methysticin exhibited time-,… read more here.
Keywords: mechanism based; cyp2c9; cytochrome p450; p450 ... See more keywords
Cytochrome P450 2C9 gene polymorphism and warfarin maintenance dosage in pediatric patients: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Therapeutics"
DOI: 10.1111/1755-5922.12230
Abstract: AIM To assess the effect of Cytochrome P450 2C9 (CYP2C9) gene polymorphism on pediatric warfarin maintenance dosage requirement. METHODS A previously developed search strategy was conducted in PubMed, EMBASE, and the Cochrane Library. Eligible studies… read more here.
Keywords: gene polymorphism; cyp2c9; warfarin maintenance; maintenance ... See more keywords
Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001245
Abstract: Icaritin (ICT) is a prenylflavonoid derivative that has been approved by National Medical Products Administration for the treatment of hepatocellular carcinoma. This study aims to evaluate the potential inhibitory effect of ICT against cytochrome P450… read more here.
Keywords: ict; cyp2c9; icaritin; drug ... See more keywords
Response to Comment on “Expectation for Prediction Models for Prothrombin Time International Normalized Ratio Under Warfarinization for Safety Use in the Era of Precision Medicine”
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DOI: 10.1177/10600280211018786
Abstract: We thank the authors for their insightful comments on our recent article on the association between the prothrombin time international normalized ratio and concomitant use of antibiotics in warfarin users.1 We agree that for our… read more here.
Keywords: precision; study; cyp2c9; medicine ... See more keywords
Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30
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DOI: 10.1371/journal.pone.0197249
Abstract: Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic variant CYP2C9*30 (A477T) is associated to diminished response to the antihypertensive effects of the prodrug losartan and affected metabolism of other drugs.… read more here.
Keywords: cyp2c9; drug; human cyp2c9; molecular mechanisms ... See more keywords
Clinical significance of the series of CYP2C9*non3 variants, an unignorable predictor of warfarin sensitivity in Chinese population
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1052521
Abstract: Backgrounds Gene polymorphisms are critical for variations in warfarin dose. To date, more than 70 CYP2C9 alleles have been identified. This study was designed to clarify the clinical significance of CYP2C9*non-3 variants to warfarin sensitivity… read more here.
Keywords: sensitivity chinese; cyp2c9; warfarin sensitivity; non variants ... See more keywords
Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.895169
Abstract: Warfarin has been widely used as an oral anticoagulant agent. In past, efforts have been done to study the contribution of genetic variation on warfarin dose requirements. The possible therapeutic dose determination of warfarin is… read more here.
Keywords: valve replacement; cyp2c9; vkorc1 cyp2c9; patients heart ... See more keywords