Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.807
Abstract: Our recent studies have shown that chronic kidney disease (CKD) affects the pharmacokinetics (PKs) of cytochrome P450 (CYP)2D6‐metabolized drugs, whereas effects were less evident on CYP3A4/5. Therefore, the effect of CKD on the disposition of… read more here.
Keywords: cyp2c9; cyp2c8; effect; cyp2c9 cyp2c19 ... See more keywords
Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally
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DOI: 10.1007/s12325-019-01075-5
Abstract: Exogenous progesterone is prescribed for a variety of conditions with endogenous progesterone deficiency, e.g. menstrual alterations, primary or secondary infertility or premenopause. To the best of our knowledge, no pharmacogenetic studies have been published in… read more here.
Keywords: disposition; safety; cyp2c9 cyp2c19; safety metabolism ... See more keywords
Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.11.016
Abstract: Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms in cytochromes P450 (CYPs) drive inter-phenotypic differences and may… read more here.
Keywords: inter phenotypic; metabolism; variability; cyp2c9 cyp2c19 ... See more keywords
Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2020 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2020.1780577
Abstract: Abstract Chronic obstructive pulmonary disease (COPD) is a high incidence in the elderly and significantly affects the quality of life. CYP2C9 and CYP2C19 play an important role in tobacco-related diseases and inflammatory reactions. Thus, we… read more here.
Keywords: chronic obstructive; risk; obstructive pulmonary; copd ... See more keywords
Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics.
Sign Up to like & getrecommendations! Published in 2018 at "Omics A Journal of Integrative Biology"
DOI: 10.1089/omi.2018.0114
Abstract: Abstract Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characte... read more here.
Keywords: variability cyp2d6; cyp2d6 cyp2c9; ribef ceiba; consortium ... See more keywords
Drug metabolizing enzymes pharmacogenomic: Biomarkers for improved chemotherapy in head and neck cancer squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz431.019
Abstract: Abstract Background Much of the inter-individual differences in the regulation, expression, and activity of drug metabolizing enzymes genes might be crucial factors in defining cancer susceptibility, as well as in determining the efficacy of drugs.… read more here.
Keywords: neck cancer; drug metabolizing; metabolizing enzymes; cyp2c9 cyp2c19 ... See more keywords
Genetic and phenotypic frequency distribution of CYP2C9, CYP2C19 and CYP2D6 in over 3200 Han Chinese
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13357
Abstract: This retrospective study analyzed the polymorphisms and phenotypic frequencies of CYP2C9, CYP2C19 and CYP2D6 in a Han Chinese population. read more here.
Keywords: cyp2c19 cyp2d6; cyp2c9 cyp2c19; phenotypic; han chinese ... See more keywords
Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_706_22
Abstract: OBJECTIVE: Human cytochrome p450 enzymes play an important role in the metabolism of various substances. The CYP2C subfamily consists of various important drug-metabolizing enzymes such as CYP2C9 and CYP2C19. The objectives of the study include… read more here.
Keywords: clopidogrel efficacy; cyp2c19; cyp2c19 variant; cyp2c9 cyp2c19 ... See more keywords