Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite
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DOI: 10.1007/s12272-016-0861-2
Abstract: Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis. The predominant hepatic metabolism of celecoxib to celecoxib carboxylic acid (CCA) is mediated mainly by CYP2C9. We investigated the… read more here.
Keywords: pharmacokinetics celecoxib; celecoxib; cyp2c9 genetic; carboxylic acid ... See more keywords