The impact of the CYP2D6 "enhancer" single nucleotide polymorphism on CYP2D6 activity.
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DOI: 10.1002/cpt.2469
Abstract: rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP),… read more here.
Keywords: cyp2d6; enhancer snp; cyp2d6 activity; impact cyp2d6 ... See more keywords
Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic Acid as a Urinary Biomarker of CYP2D6 Activity
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000957
Abstract: Cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, including antidepressants and antipsychotics, and its activity varies considerably on a population basis, primarily because of genetic… read more here.
Keywords: cyp2d6; solanidine; biomarker cyp2d6; activity ... See more keywords
Long-Distance Phasing of a Tentative “Enhancer” Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions
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DOI: 10.3389/fphar.2020.00486
Abstract: Background The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements.… read more here.
Keywords: cyp2d6; enhancer snp; star; cyp2d6 activity ... See more keywords
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study
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DOI: 10.3389/fphar.2021.624104
Abstract: Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance. This study aimed to… read more here.
Keywords: cyp2d6 activity; dizziness; drug; saturation ... See more keywords