Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.
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DOI: 10.1016/j.dmpk.2018.08.004
Abstract: Cytochrome P450 2D6 (CYP2D6) is responsible for the metabolic activation of primaquine, an antimalarial drug. CYP2D6 is genetically polymorphic, and these polymorphisms are associated with interindividual variations observed in the therapeutic efficacy of primaquine. To… read more here.
Keywords: cyp2d6 allelic; cyp2d6; allelic variants; primaquine hydroxylation ... See more keywords
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.079871
Abstract: Metabolic phenotype can be affected by multiple factors, including allelic variation and interactions with inhibitors. Human CYP2D6 is responsible for approximately 20% of cytochrome P450–mediated drug metabolism but consists of more than 100 known variants;… read more here.
Keywords: cyp2d6 allelic; metabolism; inactivation sch; nadph coupling ... See more keywords