Transcriptional Regulation of CYP2D6 Expression
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DOI: 10.1124/dmd.116.072249
Abstract: CYP2D6-mediated drug metabolism exhibits large interindividual variability. Although genetic variations in the CYP2D6 gene are well known contributors to the variability, the sources of CYP2D6 variability in individuals of the same genotype remain unexplained. Accumulating… read more here.
Keywords: cyp2d6; cyp2d6 expression; regulation cyp2d6; transcriptional regulation ... See more keywords
Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6.
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism letters"
DOI: 10.2174/1872312811666170407164631
Abstract: BACKGROUND Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, responsible for eliminating 25% of marketed drugs. We recently identified SHP as a negative regulator of CYP2D6 expression and showed that factors that alter SHP… read more here.
Keywords: p450 cyp; expression; cyp 2d6; cytochrome p450 ... See more keywords