Associations of polymorphisms of CYP2D6 and CYP2C9 with early onset severe pre-eclampsia and response to labetalol therapy
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DOI: 10.1007/s00404-018-4791-8
Abstract: PurposeEarly onset preeclampsia (PPE) contributes to life-threatening maternal complications and fetal demise. Pharmacogenomics is a precision medicine, and metabolizing enzymes responsive to antihypertensive remains understudied. The aim of this study was to evaluate the associations… read more here.
Keywords: cyp2d6 cyp2c9; associations polymorphisms; labetalol; cyp2d6 gene ... See more keywords
Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abf3637
Abstract: A neural network model trained on full CYP2D6 gene sequences increases the ability to predict CYP2D6-mediated tamoxifen metabolism. A prescription for dosing prediction The highly polymorphic enzyme cytochrome P450 2D6 (CYP2D6) processes about a quarter… read more here.
Keywords: cyp2d6 gene; drug response; drug; cyp2d6 ... See more keywords
CYP2D6 Gene Polymorphisms and Variable Metabolic Activity in Schizophrenia Patients of Han and Tibetan Populations
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DOI: 10.2147/ndt.s355985
Abstract: Background It has been suggested that the pharmacogenomic response to antipsychotics in schizophrenia patients partially contributed by drug metabolism enzyme polymorphism, including P450 2D6 (CYP2D6). However, CYP2D6 gene polymorphism across populations is largely unknown. Materials… read more here.
Keywords: han tibetan; schizophrenia patients; cyp2d6 gene; tibetan patients ... See more keywords
CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine
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DOI: 10.3389/fphar.2022.985159
Abstract: This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic… read more here.
Keywords: fluvoxamine; cyp2d6 gene; profile; cyp2d6 ... See more keywords
Untangling SNP Variations within CYP2D6 Gene in Croatian Roma
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DOI: 10.3390/jpm12030374
Abstract: CYP2D6 is a highly polymorphic gene whose variations affect its enzyme activity. To assess whether the specific population history of Roma, characterized by constant migrations and endogamy, influenced the distribution of alleles and thus phenotypes,… read more here.
Keywords: cyp2d6 gene; roma groups; roma; croatian roma ... See more keywords
Relevance of CYP2D6 Gene Variants in Population Genetic Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112481
Abstract: A significant portion of the variability in complex features, such as drug response, is likely caused by human genetic diversity. One of the highly polymorphic pharmacogenes is CYP2D6, encoding an enzyme involved in the metabolism… read more here.
Keywords: cyp2d6 gene; populations form; cyp2d6; african populations ... See more keywords