Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients.
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DOI: 10.1007/s00228-020-03002-y
Abstract: PURPOSE Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI administrations without and… read more here.
Keywords: exposure; zuclopenthixol; cyp2d6 genotype; study ... See more keywords
Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.
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DOI: 10.1097/ftd.0000000000001096
Abstract: BACKGROUND Paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome P450 (CYP)2D6. Only small-scale studies have reported the impact of CYP2D6 genotype on paroxetine exposure, and international guidelines differ in their recommendations on whether… read more here.
Keywords: paroxetine; cyp2d6; impact cyp2d6; cyp2d6 genotype ... See more keywords
CYP2D6 Genotype-Based Dose Recommendations for Risperidone in Asian People
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DOI: 10.3389/fphar.2020.00936
Abstract: The aim of this study was to provide dose recommendations for risperidone in Asian people based on cytochrome P450 enzyme CYP2D6 genotype. First, we investigated the influence of CYP2D6 polymorphism on the pharmacokinetics of risperidone… read more here.
Keywords: dose recommendations; recommendations risperidone; risperidone asian; cyp2d6 genotype ... See more keywords