A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300571
Abstract: Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into N-acetyl-p-benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting… read more here.
Keywords: cyp2e1; liver; liver failure; acute liver ... See more keywords
Quantification of CYP2E1 in rat liver by UPLC-MS/MS-based targeted proteomics assay: a novel approach for enzyme activity assessment
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02757-8
Abstract: CYP2E1 is one of the most crucial isozymes of CYP450. It is responsible for metabolizing and activating a large number of toxicants and carcinogens, but the correlation between its abundance and activity has not been… read more here.
Keywords: cyp2e1; cyp2e1 rat; correlation; abundance ... See more keywords
Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2479-4
Abstract: To the Editor We read a recent publication by Bedada and Neerati on European Journal of Clinical Pharmacology with great interest, reporting the plasma concentrations of chlorzoxazone, an in vivo CYP2E1 probe drug, being significantly… read more here.
Keywords: cyp2e1; chlorzoxazone; drug; pharmacology ... See more keywords
Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108677
Abstract: We investigate the effect of the alcohol-induced increase in the content of CYP2E1 in human liver microsomes (HLM) on the function of CYP3A4. Membrane incorporation of the purified CYP2E1 into HLM considerably increases the rate… read more here.
Keywords: induced increase; cyp2e1; hlm; alcohol induced ... See more keywords
Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.
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DOI: 10.1021/acs.est.8b05250
Abstract: Exposure to chiral polychlorinated biphenyls (PCBs) has been associated with neurodevelopmental disorders. Their hydroxylated metabolites (OH-PCBs) are also potentially toxic to the developing human brain; however, the formation of OH-PCBs by human cytochrome P450 (P450)… read more here.
Keywords: hydroxylated metabolites; cyp2a6 cyp2b6; polychlorinated biphenyls; cyp2e1 ... See more keywords
Toxicological Implications of Mitochondrial Localization of CYP2E1.
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DOI: 10.1039/c7tx00020k
Abstract: Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of… read more here.
Keywords: cyp2e1; toxicological implications; localization cyp2e1; implications mitochondrial ... See more keywords
Contributions of caspase-8 and -9 to liver injury from CYP2E1-produced metabolites of halogenated hydrocarbons
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DOI: 10.1080/00498254.2016.1275881
Abstract: Abstract 1. Drug-induced liver injury is difficult to predict at the pre-clinical stage. This study aimed to clarify the roles of caspase-8 and -9 in CYP2E1 metabolite-induced liver injury in both rats and cell cultures in… read more here.
Keywords: cyp2e1; caspase activities; liver injury; culture ... See more keywords
Polymorphisms of drug-metabolizing enzyme CYP2E1 in Chinese Uygur population
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DOI: 10.1097/md.0000000000009970
Abstract: Abstract Pharmacogenetics is the genetic basis of pharmacokinetics, genetic testing, and clinical management in diseases. Evaluation about genetic alterations of drug metabolizing enzymes in human genome contributes toward understanding the interindividual and interethnic variability for… read more here.
Keywords: drug metabolizing; cyp2e1; uygur population; metabolizing enzyme ... See more keywords
Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats
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DOI: 10.1177/0748233719839847
Abstract: Cytochrome P450 2E1 (CYP2E1) can be induced by diabetes mellitus, nonalcoholic liver disease, and obesity. This study assessed the protective effects of three sulfur compounds, namely phenethyl isothiocyanate (PEITC), dimethyl trisulfide (DMTS), and sodium thiosulfate… read more here.
Keywords: cyp2e1; acute toxicity; cyp2e1 induced; protective effects ... See more keywords
Effect of Ethanol Consumption on the Placenta and Liver of Partially IGF-1-Deficient Mice: The Role of Metabolism via CYP2E1 and the Antioxidant Enzyme System
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11091264
Abstract: Simple Summary Ethanol is the most consumed drug worldwide, even during pregnancy. One of its adverse outcomes is fetal growth restriction, an alteration in development due to decreased IGF-1 levels. Several studies have shown that… read more here.
Keywords: cyp2e1; system; ethanol consumption; mice ... See more keywords
Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models
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DOI: 10.3390/biology9120419
Abstract: Simple Summary Cytochrome P450 CYP2E1 is an enzyme engaged in the breakdown of various compounds (drugs, carcinogens, dietary nutrients and toxins) as well as endogenous compounds (steroids and fatty acids), resulting in both detoxification and… read more here.
Keywords: cyp2e1 elevation; cyp2e1; nafld nash; hepatic cyp2e1 ... See more keywords