Propolis alleviates 4‐aminobiphenyl‐induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells
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DOI: 10.1002/tox.23147
Abstract: 4‐Aminobiphenyl (4‐ABP) may cause DNA damage in human liver cells (HepG2 and L‐02). Propolis exhibits antioxidant properties through reactive oxygen species (ROS) scavenging. We determined the effects of propolis in alleviating 4‐ABP ‐induced DNA damage… read more here.
Keywords: dna damage; cyp2e1 expression; oxidative dna; dna ... See more keywords
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity
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DOI: 10.1080/00498254.2022.2128934
Abstract: Abstract CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and… read more here.
Keywords: cyp2e1 expression; rev erb; erb; hepatotoxicity ... See more keywords