Propolis alleviates 4‐aminobiphenyl‐induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells
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DOI: 10.1002/tox.23147
Abstract: 4‐Aminobiphenyl (4‐ABP) may cause DNA damage in human liver cells (HepG2 and L‐02). Propolis exhibits antioxidant properties through reactive oxygen species (ROS) scavenging. We determined the effects of propolis in alleviating 4‐ABP ‐induced DNA damage… read more here.
Keywords: dna damage; cyp2e1 expression; oxidative dna; dna ... See more keywords
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2128934
Abstract: Abstract CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and… read more here.
Keywords: cyp2e1 expression; rev erb; erb; hepatotoxicity ... See more keywords
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells
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DOI: 10.1186/s10020-024-00844-5
Abstract: Increased level of serum cholic acid (CA) is often accompanied with decreased CYP2E1 expression in hepatocellular carcinoma (HCC) patients. However, the roles of CA and CYP2E1 in hepatocarcinogenesis have not been elucidated. This study aimed… read more here.
Keywords: cyp2e1; cyp2e1 expression; hcc; expression ... See more keywords
Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure
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DOI: 10.3390/biomedicines13102446
Abstract: Background/Objectives: Acetaminophen (APAP) is used during 50–60% of pregnancies in the U.S. and has been associated with childhood respiratory morbidity, though the underlying mechanism remains unclear. APAP-induced injury is dependent on cell-specific expression of CYP2E1,… read more here.
Keywords: cyp2e1 expression; apap; transcriptional response; response maternal ... See more keywords