Effect and mechanism of vitamin D activation disorder on liver fibrosis in biliary atresia
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99158-3
Abstract: To investigate the mechanism of 25 hydroxyvitamin D (25(OH)D) deficiency in children with biliary atresia (BA) and its effect on liver fibrosis. The serum vitamin D and 25(OH)D, and expression of 25 hydroxylase (CYP2R1 and… read more here.
Keywords: fibrosis; liver fibrosis; cyp2r1; effect ... See more keywords
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01065-3
Abstract: Background Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin… read more here.
Keywords: vitamin metabolism; cyp2r1; bmi; genetic variants ... See more keywords
Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03028
Abstract: The prevalence of vitamin D deficiency, as determined by circulating levels of 25-hydroxycalciferol [25(OH)D], is greater in older individuals compared with the young. To examine the hypothesis that altered production or inactivation of 25(OH)D contributes… read more here.
Keywords: transcripts encoding; way anova; cyp2r1; hepatic cyp2r1 ... See more keywords
Vitamin D levels and Vitamin D-related gene polymorphisms in Chinese children with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.965296
Abstract: Low vitamin D levels may play a role in type 1 diabetes (T1D) susceptibility. Since 25(OH)D synthesis is genetically regulated, single nucleotide polymorphisms (SNPs) of important genes have also been shown to modulate the risk… read more here.
Keywords: vitamin levels; chinese children; t1d; risk ... See more keywords
Association of CYP2R1 and VDR Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents
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DOI: 10.3390/nu14214612
Abstract: Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of CYP2R1 and VDR variants with… read more here.
Keywords: polymorphism; components non; metabolic syndrome; cyp2r1 vdr ... See more keywords