RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription
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DOI: 10.1126/sciadv.adf5330
Abstract: Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant homeodomain (PHD3) domain. Through an unknown mechanism, MLL1 activity is… read more here.
Keywords: rna binding; cyp33; switch; mll1 ... See more keywords