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Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.086637
Abstract: The primary bile acids (BAs) synthesized from cholesterol in the liver are converted to secondary BAs by gut microbiota. It was recently disclosed that the major secondary BA, deoxycholate (DCA) species, is stereoselectively oxidized to…
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Keywords:
oxidation;
hydroxylation;
dca;
cyp3a enzymes ... See more keywords