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Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.586
Abstract: Amenamevir (formerly ASP2151) is a helicase‐primase inhibitor being developed for the treatment of herpesvirus infection. Amenamevir is both a substrate and inducer of cytochrome P450 (CYP) 3A4. Three studies were done in healthy volunteers to…
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Keywords:
cyp3a mediated;
cyp3a;
healthy volunteers;
geometric mean ... See more keywords
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Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000318
Abstract: Solithromycin is a novel fluoroketolide antibiotic that is both a substrate and time-dependent inhibitor of CYP3A. Solithromycin has demonstrated efficacy in adults with community-acquired bacterial pneumonia and has also been investigated in pediatric patients. The…
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Keywords:
cyp3a mediated;
based pharmacokinetic;
cyp3a;
ddi potential ... See more keywords