Reversing effects of ginsenosides on LPS-induced hepatic CYP3A11/3A4 dysfunction through the pregnane X receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.09.041
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ginseng (Panax ginseng C. A. Meyer), a traditional Chinese medicine, is widely used in the adjunctive therapy of the liver diseases. AIM OF THE STUDY Ginsenosides are one kind of the main active… read more here.
Keywords: cyp3a11; liver; expression; hepg2 cells ... See more keywords
KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury
Sign Up to like & getrecommendations! Published in 2024 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.123.001617
Abstract: Rifampicin (RFP) has demonstrated potent antibacterial effects in the treatment of pulmonary tuberculosis. However, the serious adverse effects on the liver intensively limit the clinical usage of the drug. Deacetylation greatly reduces the toxicity of… read more here.
Keywords: liver injury; klf15 cyp3a11; cyp3a11; rfp ... See more keywords