Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Impact of Chronic Kidney Disease on CYP3A4‐Mediated Metabolism of Saxagliptin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2043
Abstract: We characterized the impact of chronic kidney disease (CKD) on the cytochrome P450 (CYP) 3A4–mediated metabolism of saxagliptin to its metabolite, 5‐hydroxysaxagliptin, using a physiologically based pharmacokinetic (PBPK) model. A PBPK model of saxagliptin and… read more here.
Keywords: metabolism saxagliptin; cyp3a4 activity; cyp3a4; impact ... See more keywords
P.1.019 Phenazepam's safety pharmacogenetic study results: influence of CYP2C9, CYP3A5, CYP2C19, ABCB1 and CYP3A4/5 isoenzymes' activity
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.037
Abstract: Introduction Bromdihydrochlorphenylbenzodiazepine (Phenazepam) is the Russian original benzodiazepine, which was widely prescribed in post-Soviet countries. The chemical structure is close to clonazepam [1]. Alcohol withdrawal syndrome is one from the most frequent indications for Phenazepam.… read more here.
Keywords: safety; cyp3a4 activity; cyp3a4; cyp2c19 ... See more keywords