Articles with "cyp3a4 cpr" as a keyword



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Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.

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Published in 2017 at "Drug metabolism and pharmacokinetics"

DOI: 10.1016/j.dmpk.2016.08.004

Abstract: The Caco-2 cells co-expressing cytochrome P450 (CYP) 3A4 and NADPH-cytochrome P450 reductase (CPR) were developed using a human artificial chromosome (HAC) vector. The CYP3A4 and CPR genes were cloned into the HAC vector in CHO cells… read more here.

Keywords: hac; caco cells; cyp3a4; cyp3a4 cpr ... See more keywords