Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.
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DOI: 10.1016/j.dmpk.2018.01.004
Abstract: The first-order degradation rate constant (kdeg) of cytochrome P450 (CYP) enzymes is a known source of uncertainty in the prediction of time-dependent drug-drug interactions (DDIs) in physiologically-based pharmacokinetic (PBPK) modelling. This study aimed to measure… read more here.
Keywords: degradation rate; cyp3a4 cyp2b6; cyp3a4; primary human ... See more keywords