Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.9935
Abstract: In this study, we investigated the effect of silybin on the pharmacokinetics of brexpiprazole and the underlying mechanism in rats. Two groups of animals received silybin at different doses (50 mg/kg, 25 mg/kg) for 2… read more here.
Keywords: concentration brexpiprazole; blood concentration; cyp3a4 cyp2d6; brexpiprazole ... See more keywords
Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911458
Abstract: Drug metabolizing enzyme activity is affected by various factors such as drug–drug interactions, and a method to quantify drug metabolizing enzyme activity in real time is needed. In this study, we developed a novel radiopharmaceutical… read more here.
Keywords: activity; hepatic cyp3a4; cyp3a4 cyp2d6; cyp3a4 ... See more keywords