Genotyping and phenotyping CYP3A4\CYP3A5: no association with antiplatelet effect of clopidogrel
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04871-y
Abstract: The objective of this study was to determine the impact of polymorphism of CYP3A subfamily isoenzymes (allelic variants of CYP3A4*22 and CYP3A5*3) on the efficacy clopidogrel in patients with an acute coronary syndrome (ACS), who… read more here.
Keywords: clopidogrel; cyp3a4 cyp3a5; phenotyping cyp3a4; antiplatelet effect ... See more keywords
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.
Sign Up to like & getrecommendations! Published in 2017 at "Fitoterapia"
DOI: 10.1016/j.fitote.2017.03.010
Abstract: Gomisin C (GC) and gomisin G (GG) are two lignan analogs isolated from the Traditional Chinese Medicine Schisandra chinensis which possesses multiple pharmacological activities. However, the potential herb-drug interactions (HDI) between these lignans and other… read more here.
Keywords: gomisin; cyp3a4 cyp3a5; cyp3a5; cyp3a4 ... See more keywords
Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298 and 451a levels
Sign Up to like & getrecommendations! Published in 2018 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1555344
Abstract: Abstract 1. Scutellarin is a flavonoid glycoside widely used in the treatment of cardio-cerebrovascular diseases in China. In this study, we investigated the effect of scutellarin on cytochrome P450 3A4 (CYP3A4) and CYP3A5 expression. Furthermore,… read more here.
Keywords: hsa mir; cyp3a4 cyp3a5; hsa; cyp3a5 expression ... See more keywords
Genetic Association in CYP3A4 and CYP3A5 genes elevate the risk of Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of human biology"
DOI: 10.1080/03014460.2023.2171122
Abstract: BACKGROUND CYP3A4 and CYP3A5 are biologically potential genes responsible for prostate cancer. AIM We aimed to analyse the expression and association of CYP3A4 and CYP3A5 genes in prostate cancer. SUBJECTS AND METHODS Web-based bioinformatics tools… read more here.
Keywords: prostate cancer; cancer; cyp3a4 cyp3a5;
Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13398
Abstract: The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements… read more here.
Keywords: regulatory variants; expression; cyp3a4 cyp3a5; cyp3a4 ... See more keywords
Effect of CYP3A4∗1G and CYP3A5∗3 Polymorphisms on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00176
Abstract: Ticagrelor is the first reversible, direct-acting, potent P2Y12 receptor antagonist in management of acute coronary syndromes. It is rapidly absorbed and extensively metabolized. AR-C124910XX, the major active metabolite, antagonizes the P2Y12 receptor at approximately equal… read more here.
Keywords: c124910xx; cyp3a4 cyp3a5; ticagrelor; effect ... See more keywords
Effects of CYP3A4*22 and CYP3A5 on clinical outcome in patients treated with ticagrelor for ST-segment elevation myocardial infarction: POPular Genetics sub-study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1032995
Abstract: Aims: To determine the clinical efficacy, adverse events and side-effect dyspnea of CYP3A4*22 and CYP3A5 expressor status in ticagrelor treated patients. Methods and results: Ticagrelor treated patients from the POPular Genetics randomized controlled trial were… read more here.
Keywords: popular genetics; myocardial infarction; cyp3a4 cyp3a5; cyp3a4 ... See more keywords
Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients’ Population
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph17103692
Abstract: Single nucleotide polymorphism (SNP) in genes encoding drug-metabolizing enzymes (DME) could have a critical role in individual responses to anastrozole. Frequency of CYP3A4*1B, CYP3A5*3 and UGT1A4*2 SNPs in 126 Croatian breast cancer (BC) patients and… read more here.
Keywords: cyp3a5 ugt1a4; croatian breast; cyp3a4 cyp3a5; breast cancer ... See more keywords