TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration‐Resistant Prostate Cancer
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DOI: 10.1002/cpt.907
Abstract: The testis‐specific Y‐encoded‐like protein (TSPYL) gene family includes TSPYL1 to TSPYL6. We previously reported that TSPYL5 regulates cytochrome P450 (CYP) 19A1 expression. Here we show that TSPYLs, especially TSPYL 1, 2, and 4, can regulate… read more here.
Keywords: response; cyp3a4 expression; metastatic castration; expression ... See more keywords
Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia
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DOI: 10.1038/s41598-020-78474-0
Abstract: Clozapine is effective in treatment-resistant schizophrenia; however, adverse effects often result in discontinuation of clozapine therapy. Many of the side-effects are associated with pharmacokinetic variations; therefore, the expression of major clozapine-metabolizing enzymes (CYP1A2, CYP3A4) in… read more here.
Keywords: clozapine; patients schizophrenia; cyp3a4 expression; expression ... See more keywords
Effect of Crohn’s Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine
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DOI: 10.1111/cts.12938
Abstract: Changes in absorptive capacity and first‐pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing physiologically‐based pharmacokinetic (PBPK) models for inflammatory bowel… read more here.
Keywords: length; villous length; cyp3a4 expression; length cyp3a4 ... See more keywords