Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro
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DOI: 10.1111/jphp.13153
Abstract: Macitentan is a new choice for pulmonary hypertension treatment which is converted to active metabolite ACT132577 by human cytochrome P450 3A4. Human cytochrome P450 3A4 often occurred gene mutations. Gene polymorphism might cause a variety… read more here.
Keywords: variants macitentan; metabolism; macitentan metabolism; functional characterization ... See more keywords
Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
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DOI: 10.1124/dmd.120.000261
Abstract: CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs. Therefore, interindividual variability in CYP3A4 activity is a frequent cause… read more here.
Keywords: testosterone hydroxylation; hydroxylation; drug; cyp3a4 variants ... See more keywords
Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro
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DOI: 10.2147/idr.s215129
Abstract: Background Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which in turn contributes to interindividual variability in response to therapeutic drugs. Loperamide, identified as a CYP3A4 substrate, is prone to misuse and abuse and… read more here.
Keywords: cyp3a4 variants; functional characteristics; characteristics cyp3a4; cyp3a4 ... See more keywords