Metabolism of the antipsychotic drug olanzapine by CYP3A43
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DOI: 10.1080/00498254.2022.2078751
Abstract: Abstract 1. Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. An intronic single nucleotide polymorphism (SNP) that highly significantly predicts increased olanzapine clearance (rs472660) was previously identified in the CYP3A43… read more here.
Keywords: metabolism; olanzapine cyp3a43; antipsychotic drug; cyp3a43 ... See more keywords
Changes in Alprazolam Metabolism by CYP3A43 Mutants
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DOI: 10.3390/biomedicines10123022
Abstract: Alprazolam is a triazolobenzodiazepine which is most commonly used in the short-term management of anxiety disorders, often in combination with antipsychotics. The four human members of the CYP3A subfamily are mainly responsible for its metabolism,… read more here.
Keywords: metabolism; cyp3a43 mutants; cyp3a43; production rates ... See more keywords
Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function
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DOI: 10.3390/ijms231810554
Abstract: Presenilin-1 (PSEN1) is a crucial subunit within the γ-secretase complex and regulates β-amyloid (Aβ) production. Accumulated evidence indicates that n-butylidenephthalide (BP) acts effectively to reduce Aβ levels in neuronal cells that are derived from trisomy… read more here.
Keywords: mir 29b; psen1 lnc; cyp3a43; lnc cyp3a43 ... See more keywords
Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance
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DOI: 10.3390/ijms24010113
Abstract: The cytochrome P450s (CYP450s) include key oxidative enzymes involved in the metabolism of various carcinogens and anticancer drugs. Bioinformatic studies have demonstrated the association of CYP3A43 with liver cancer and ovarian cancer. However, the biological… read more here.
Keywords: cyp3a43; cell; cell proliferation; lung adenocarcinoma ... See more keywords