Effects of clotrimazole on tacrolimus pharmacokinetics in patients with heart transplants with different CYP3A5 genotypes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2558-6
Abstract: PurposeThis study aimed to investigate the effects of clotrimazole on the pharmacokinetics of tacrolimus in Japanese patients with heart transplants with different CYP3A5 genotypes.MethodsTwenty-six patients who underwent heart transplantation between June 2012 and July 2017… read more here.
Keywords: cyp3a5 genotypes; heart transplants; cyp3a5; patients heart ... See more keywords
Polymorphic variants of drug-metabolizing enzymes alter the risk and survival of oral cancer patients
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DOI: 10.1007/s13205-020-02526-5
Abstract: The present study investigated the prevalence of CYP2D6*4, CYP3A5*3 and SULT1A1*2, using PCR–RFLP, in normal and oral cancer (OC) patients that were stratified by OC subtype and gender. The risk of cancer, 5-year cumulative survival… read more here.
Keywords: risk; risk survival; oral cancer; cyp3a5 ... See more keywords
Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms.
Sign Up to like & getrecommendations! Published in 2021 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2021.100407
Abstract: We evaluated the impact of vonoprazan on blood concentrations of tacrolimus via a retrospective analysis of 52 renal transplant recipients who took tacrolimus and converted from rabeprazole to vonoprazan between August 2018 and September 2019.… read more here.
Keywords: blood concentrations; conversion; concentrations tacrolimus; upon conversion ... See more keywords
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.
Sign Up to like & getrecommendations! Published in 2017 at "Fitoterapia"
DOI: 10.1016/j.fitote.2017.03.010
Abstract: Gomisin C (GC) and gomisin G (GG) are two lignan analogs isolated from the Traditional Chinese Medicine Schisandra chinensis which possesses multiple pharmacological activities. However, the potential herb-drug interactions (HDI) between these lignans and other… read more here.
Keywords: gomisin; cyp3a4 cyp3a5; cyp3a5; cyp3a4 ... See more keywords
Tacrolimus Therapeutic Drug Monitoring in Stable Kidney Transplantation and Individuation of CYP3A5 Genotype.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.04.090
Abstract: The posology of tacrolimus (TAC) is usually guided by its therapeutic drug monitoring. Some patients reach target concentrations (CTs) quickly, others more slowly. In a retrospective study, 20 kidney transplant recipients were included (mean age,… read more here.
Keywords: cyp3a5 genotype; group; genotype; therapeutic drug ... See more keywords
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease
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DOI: 10.1038/s41598-021-84194-w
Abstract: CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and… read more here.
Keywords: renal disease; expression; cyp3a5 renal; cyp3a5 expression ... See more keywords
Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfy096
Abstract: Background Tacrolimus, a drug for prevention of rejection after kidney transplantation, has a narrow therapeutic window and is metabolized by the cytochrome P540 3A (CYP3A) system. Tacrolimus exposure increases after steroid tapering in many patients.… read more here.
Keywords: steroid tapering; increase; tacrolimus exposure; renal transplant ... See more keywords
Correlations of CYP2C9∗3/CYP2D6∗10/CYP3A5∗3 gene polymorphisms with efficacy of etanercept treatment for patients with ankylosing spondylitis
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DOI: 10.1097/md.0000000000005993
Abstract: Background: The tumor necrosis factor alpha (TNF-&agr;) inhibitor etanercept has been proven to be effective in the treatment of ankylosing spondylitis (AS), while genetic polymorphism may affect drug metabolism or drug receptor, resulting in interindividual… read more here.
Keywords: treatment; treatment patients; genotype; etanercept treatment ... See more keywords
Donor Genotype and Intragraft Expression of CYP3A5 Reflect the Response to Steroid Treatment During Acute Renal Allograft Rejection
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DOI: 10.1097/tp.0000000000001584
Abstract: Background Glucocorticoid (GC)-refractory acute rejection (AR) is a risk factor for inferior renal allograft outcome. We investigated genetic predisposition to the response to steroid treatment of acute allograft rejection. Methods Single nucleotide polymorphisms of genes… read more here.
Keywords: rejection; allograft; intragraft; expression ... See more keywords
Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end‐stage renal disease
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DOI: 10.1111/cts.13065
Abstract: Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio is affected by CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which is frequently associated with end‐stage renal disease. Recently, PTH… read more here.
Keywords: renal disease; stage renal; level; blood ... See more keywords
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.076307
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 engineering of the CYP3A5 *3 locus (rs776746) in human liver cell line HuH-7 (CYP3A5 *3/*3) has led to three CYP3A5 *1 cell lines by deletion of the exon… read more here.
Keywords: cell line; metabolism; cell lines; crispr cas9 ... See more keywords