Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.
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DOI: 10.1016/j.xphs.2017.12.007
Abstract: Icotinib is the first self-developed small molecule drug in China for targeted therapy of non-small cell lung cancer. To date, systematic studies on the pharmacokinetic drug-drug interaction of icotinib were limited. By identifying metabolite generated… read more here.
Keywords: drug interaction; drug; cyp3a5 cyp1a2; pharmacokinetic drug ... See more keywords