An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.123111
Abstract: Cancer is a complex disease with very high incidence and mortality rates every year. However, cancer drug resistance greatly mitigates the cure rates of tumors, and cytochrome P450 (CYP450) plays an important role in the… read more here.
Keywords: probe; aggregation induced; induced emission; resistance ... See more keywords
Reversion of CYP450 monooxygenase-mediated acetamiprid larval resistance in dengue fever mosquito, Aedes aegypti L.
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of Entomological Research"
DOI: 10.1017/s0007485321001140
Abstract: Abstract Aedes-borne diseases are on the rampant rise despite continued application of chemical insecticide-based interventions. The appearance of high degree of insecticide resistance in Aedes species and noxious effects on environment and non-targets have raised… read more here.
Keywords: aedes aegypti; apsf strains; acsf; cyp450 ... See more keywords
Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45212-0
Abstract: Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has… read more here.
Keywords: drug metabolizing; cyp450; drug; porcine ... See more keywords
Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1208854
Abstract: Abstract 1. Among the different in vitro studies recommended by the regulatory agencies, no gold-standard model can easily and directly measure the quantitative CYP450 contributions to drug biotransformation. In this article, we propose an original strategy,… read more here.
Keywords: cyp450; drug; clearance; cyp3a4 ... See more keywords
CYP450-Mediated Metabolism of Mitragynine and Investigation of Metabolites in Human Urine.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkz108
Abstract: Mitragyna speciosa (Kratom) has emerged as a recreational drug and a substance of medicinal intrigue. Although the drug was initially used recreationally for its sedating and euphoric effects, more recently its use has been associated… read more here.
Keywords: metabolism mitragynine; cyp450; investigation; cyp450 mediated ... See more keywords
Do cytochrome P450 2C9 pathways contribute to the cerebrovascular response to small muscle exercise?
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5795737
Abstract: Cytochrome P450 2C9 (CYP450) contributes to regulation of cerebral blood flow in animal models, however, the involvement of CYP450 in human cerebrovascular control is under researched. To this effect, small muscle exercise has been utilized… read more here.
Keywords: cyp450; physiology; small muscle; response ... See more keywords
Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1108867
Abstract: Introduction: Selaginella doederleinii Hieron is a traditional Chinese herbal medicine, the ethyl acetate extract from Selaginella doederleinii (SDEA) showed favorable anticancer potentials. However, the effect of SDEA on human cytochrome P450 enzymes (CYP450) remains unclear.… read more here.
Keywords: cyp450; inhibitory effect; effect; selaginella doederleinii ... See more keywords
Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13184598
Abstract: Simple Summary Childhood cancer patients receiving treatment containing alkylating agents are at risk of infertility, yet inter-individual variability in treatment-related ovarian damage is observed. Alkylating agents are metabolized by cytochrome P450 (CYP450) enzymes and polymorphisms… read more here.
Keywords: amh levels; risk; cyp450; effect ... See more keywords
Sex and Age Influence on Association of CYP450 Polymorphism with Midazolam Levels in Critically Ill Children
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12112797
Abstract: Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The present study aimed to determine the sex and age influence on association of CYP450 polymorphism with midazolam levels… read more here.
Keywords: midazolam; influence; midazolam levels; age ... See more keywords