Insights into the binding mechanism between α‐TOH and CYP4F2: A homology modeling, molecular docking, and molecular dynamics simulation study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30391
Abstract: α‐Tocopherol (α‐TOH) is a potent antioxidant. The concentrations of α‐TOH in plasma are closely related to human health. α‐TOH can be regulated by the metabolism of cytochrome P450 4F2 (CYP4F2). However, the atomic‐level basis for… read more here.
Keywords: cyp4f2 homology; cyp4f2; homology modeling; toh cyp4f2 ... See more keywords
Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of animal physiology and animal nutrition"
DOI: 10.1111/jpn.13547
Abstract: Dairy cattle are predisposed to disease around the time of calving due to dysfunctional inflammatory responses. Oxylipids are lipid-derived mediators that regulate all aspects of the inflammatory response, and shifts in oxylipid profiles are correlated… read more here.
Keywords: cyp4f2; production; hete production; vitamin analogs ... See more keywords
Genetic polymorphisms in CYP4F2 may be associated with lung cancer risk among females and no-smoking Chinese population
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1114218
Abstract: Background Our study aimed to explore the potential association of CYP4F2 gene polymorphisms with lung cancer (LC) risk. Methods The five variants in CYP4F2 were genotyped using Agena MassARRAY in 507 cases and 505 controls.… read more here.
Keywords: lung cancer; cyp4f2; risk; cancer risk ... See more keywords